365996-07-2

Basic information

• Product Name: 2-BROMO-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE HYDROCHLORIDE
• Synonyms: 7-tetrahydrothiazolo[5;Thiazolo[5,4-c]pyridine, 2-broMo-4,5,6,7-tetrahydro-;2-Bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine HCl;2-BROMO-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE HYDROCHLORIDE;2-broMo-4
• CAS NO: 365996-07-2
• Molecular Formula: C₆H₇BrN₂S
• Molecular Weight: 255.56
• Product Categories: CHIRAL CHEMICALS
• Mol File: 365996-07-2.mol

Chemical Properties

• Boiling Point: 341.3°C at 760 mmHg
• Flash Point: 160.2°C
• Appearance: /
• Vapor Pressure: 5.79E-05mmHg at 25°C
• CAS DataBase Reference: 2-BROMO-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE HYDROCHLORIDE(365996-07-2)
• EPA Substance Registry System: 2-BROMO-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE HYDROCHLORIDE(365996-07-2)

Safety Data

• Hazardous Substances Data: 365996-07-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-BROMO-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE HYDROCHLORIDE is used as a research chemical for the exploration of its potential applications in drug development. Its unique structure, which includes a thiazole ring fused to a pyridine ring with a bromine substitution, makes it a candidate for various biological assays and screenings aimed at identifying new pharmacological agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-BROMO-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE HYDROCHLORIDE is employed as a building block or a starting material for the synthesis of more complex molecules with potential therapeutic properties. Its chemical reactivity and structural features allow for further functionalization and optimization to enhance its pharmacological profile.
Used in Drug Discovery:
2-BROMO-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE HYDROCHLORIDE is utilized in drug discovery processes to evaluate its interaction with biological targets, such as enzymes, receptors, or other proteins. This evaluation helps in understanding its potential as a lead compound for the treatment of various diseases and conditions.
Used in Chemical Synthesis:
2-BROMO-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE HYDROCHLORIDE is also used as an intermediate in the synthesis of other related compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C6H7BrN2S.ClH/c7-6-9-4-1-2-8-3-5(4)10-6;/h8H,1-3H2;1H

Upstream product

• 365996-06-1 2-Bromo-5-tert-butoxycarbonyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 365996-05-0 tert-butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate 

Downstream Products

• 143150-92-9 2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]-pyridine 
• 1070885-59-4 C₂₇H₂₈Cl₂N₄O₄S 
• 1057650-72-2 C₂₃H₂₃ClN₄O₄S₂ 
• 1070885-15-2 C₂₆H₂₇ClN₄O₄S 
• 1070886-33-7 C₂₆H₂₆Cl₂N₄O₄S 
• 1057649-44-1 C₂₇H₃₁ClN₄O₄S₂ 
• 1352298-28-2 C₃₀H₃₅ClN₄O₄S 
• 1575608-94-4 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-phenyl-6,7-dihydrothiazolo[5,4-c]piperidine-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575608-99-9 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-chlorophenyl)-6,7-dihydrothiazolo[5,4-c]piperidine-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-00-5 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-trifluoromethylphenyl)-6,7-dihydrothiazolo[5,4-c]piperidine-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-05-0 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-methoxyphenyl)-6,7-dihydrothiazolo[5,4-c]piperidine-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-09-4 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-methylphenyl)-6,7-dihydrothiazolo[5,4-c]piperidine-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-11-8 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-fluorophenyl)-6,7-dihydrothiazolo[5,4-c]piperidine-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1575609-13-0 (2R,3R)-2-(2,4-difluorophenyl)-3-(2-(4-bromophenyl)-6,7-dihydrothiazolo[5,4-c]piperidine-5(4H)-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 

Relevant articles and documents

Design, synthesis, and structure-activity relationship studies of novel fused heterocycles-linked triazoles with good activity and water solubility

Triazoles with fused-heterocycle nuclei were designed and evaluated for their in vitro activity on the basis of the binding mode of albaconazole using molecular docking, along with SAR of antifungal triazoles. Tetrahydro-[1,2,4] triazolo[1,5-a]pyrazine and tetrahydro-thiazolo[5,4-c]pyridine nuclei were preferable to the other four fused-heterocycle nuclei investigated. Potent in vitro activity, broad spectrum and better water solubility were attained when triazoles containing nitrogen aromatic heterocycles were attached to these two nuclei. The most potent compounds 27aa and 45x, with low hERG inhibition and hepatocyte toxicity, both exhibited excellent activity against Candida, Cryptococcus, and Aspergillus spp., as well as selected fluconazole-resistant strains. A high water-soluble compound 58 (the disulfate salt of 45x) displayed unsatisfactory in vivo activity because of its poor PK profiles. Mice infected with C.alb. SC5314 and C.alb. 103 (fluconazole-resistant strain) and administered with 27aa displayed significantly improved survival rates. 27aa also showed favorable pharmacokinetic (PK) profiles.

Orally active zwitterionic factor Xa inhibitors with long duration of action

We have optimized 2-aminomethylphenylamine derivative as a factor Xa inhibitor. Several polar functional groups were introduced in the central phenyl ring, and we focused on zwitter ionic compound showing continuous inhibitory activity in oral administrat

Facile methods for preparation of thiazolopyridine and tetrahydrothiazolopyridine derivatives

The improved routes to prepare tetrahydrothiazolo[5,4-c]-pyridine-2- carboxylic acid lithium salts (2 and 3) were developed. Route A is consisted of the improved preparation of thiazolopyridine intermediates, and Route B is applicable for a large scale synthesis of tetrahydrothiazolo[5,4-c]pyridine-2- carboxylic acid derivatives. The methods we developed may serve as facile means for preparing thiazolopyridine and tetrahydrothiazolopyridine derivatives.