- Palladium-catalyzed synthesis of 5-amino-1,2,4-oxadiazoles via isocyanide insertion
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A convenient and efficient palladium-catalyzed approach has been developed for the synthesis of 5-amino-1,2,4-oxadiazoles from amidoximes and isocyanides. Various 5-amino-1,2,4-oxadiazoles were obtained in moderate to high yields under mild conditions. The key to the success of this strategy involves new C-N bond and C-O bond formation via palladium-catalyzed isocyanide insertion.
- Fu, Jin-Ping,Pan, Ying-Ming,Tang, Hai-Tao,Teng, Qing-Hu,Wang, Xu,Xie, Jia-Xing
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supporting information
p. 4936 - 4940
(2020/09/23)
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- With eliminating free radical effect of the benzopyran-containing cosmetic auxiliary material and its preparation method (by machine translation)
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The invention has disclosed a kind of scavenging free radical effect of the benzopyran-containing cosmetic auxiliary material and its preparation method, which belongs to the functional organic molecular synthesis of technical field. Technical proposal of the invention points are: the benzopyran-containing cosmetic supplementary product has the structure The invention through a new method for synthesizing a novel structure of the benzofuran compound, and to carry out the oxidation resistant research, and carry on the skin of the human body the spot pastes experiment, display under certain concentration does not have harmful effects on human body skin, and then hope that can be applied to the cosmetics, as auxiliary antioxidant additive. (by machine translation)
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- SUBSTITUTED PICOLINAMIDE KINASE INHIBITORS
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Provided are picolinamide compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
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Paragraph 0188
(2014/01/09)
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- NOVEL THERAPEUTIC COMPOUNDS
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Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.
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Page/Page column 163
(2009/03/07)
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- SYNTHESIS AND THERMOLYSIS OF SOME N-HYDROXIMOYL- AND N-HYDRAZONOYLAZOLES
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The reactions of nitrile oxides or nitrile imines with pyrazole, imidazole, 1,2,3- and 1,2,4-triazole or tetrazole derivatives yield the appropriate N-hydroximoyl- or N-hydrazonoylazoles.Thermolysis of 1-hydroximoyltetrazoles, depending on the nature of the substituents in the tetrazole ring, yields 1,2,4-oxadiazoles or 5-amino-1,2,4-oxadiazoles upon hydrazoic acid or nitrogen evolution.Under similar conditions, 1-hydrazonoyltetrazoles give 1,2,4-triazoles or 5-amino-1,2,4-triazoles while 2-hydrazonoyltetrazoles decompose to the dihydro-1,2,4,5-tetrazine derivatives.
- Plenkiewicz, Jan,Zdrojewski, Tadeusz
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p. 675 - 710
(2007/10/02)
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- Thermal Behaviour of 3-Phenyl-1,2,4-oxadiazol-5-ylhydrazines
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Depending on the substitution on the hydrazine moiety, thermolysis of 3-phenyl-1,2,4-oxadiazol-5-ylhydrazines (1)-(5) gives variable amounts of 1-amino-Δ2-1,2,4-triazolin-5-ones (13) or (17), Δ2- or Δ3-1,2,4-triazolin-5-ones (12), (18), or (19), and the s-triazine (20).A possible mechanism accounting for the products and the effects is discussed.A diradical intermediate and a hydrogen transfer from the reaction medium are suggested on the basis of the effect of benzoyl peroxide on the reaction and on the behaviour of the hydrazines (1)-(4) towards catalytic hydrogenation.
- Adembri, Giorgio,Camparini, Alfredo,Ponticelli, Fabio,Tedeschi, Piero
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p. 1703 - 1706
(2007/10/02)
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