3663-37-4

Basic information

• Product Name: 5-amino-3-phenyl-1,2,4-oxadiazole
• Synonyms: 5-amino-3-phenyl-1,2,4-oxadiazole;3-Phenyl-1,2,4-oxadiazol-5-amine;1,2,4-Oxadiazol-5-amine, 3-phenyl-;Ai3-61762;Einecs 222-918-2;3-Phenyl-[1,2,4]oxadiazol-5-ylamine
• CAS NO: 3663-37-4
• Molecular Formula: C₈H₇N₃O
• Molecular Weight: 161.16068
• EINECS: 222-918-2
• Mol File: 3663-37-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 332.3°Cat760mmHg
• Flash Point: 154.7°C
• Appearance: /
• Density: 1.276g/cm³
• Vapor Pressure: 0.000148mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 5-amino-3-phenyl-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-3-phenyl-1,2,4-oxadiazole(3663-37-4)
• EPA Substance Registry System: 5-amino-3-phenyl-1,2,4-oxadiazole(3663-37-4)

Safety Data

• Hazardous Substances Data: 3663-37-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H7N3O/c9-8-10-7(11-12-8)6-4-2-1-3-5-6/h1-5H,(H2,9,10,11)

Upstream product

• 64734-30-1 N-(tert-butyl)-3-phenyl-1,2,4-oxadiazol-5-amine 
• 100-47-0 benzonitrile 
• 613-92-3 N-hydroxybenzamidine 
• 1111-78-0 ammonium carbamate 
• 827-44-1 5-chloro-3-phenyl-1,2,4-oxadiazole 
• 6041-23-2 methyl N-cyanobenzenecarboximidoate 
• 7627-10-3 3-phenyl-1,2,4-oxadiazol-5-ylhydrazine 
• 100-52-7 benzaldehyde 
• 4418-61-5 5-aminotetrazole 
• 698-16-8 benzohydroximoyl chloride 
• 506-68-3 bromocyane 
• 613-92-3 N-hydroxybenzenecarboximidamide 

Downstream Products

• 26899-34-3 N-(3-phenyl-[1,2,4]oxadiazol-5-yl)-propionamide 
• 716-90-5 N-(3-phenyl-[1,2,4]oxadiazol-5-yl)-acetamide 
• 26899-28-5 4-benzoyl-5-benzoylimino-3-phenyl-4,5-dihydro-[1,2,4]oxadiazole 
• 54034-38-7 1-methyl-3-phenyl-1,2,4-triazolin-5-one 
• 939-07-1 3-phenyl-1,2,4-triazolin-5-one 
• 78414-72-9 1-amino-3-phenyl-Δ²-1,2,4-triazolin-5-one 
• 16219-33-3 5-methylamino-3-phenyl-1,2,4-oxadiazole 
• 16219-36-6 N-benzyl-3-phenyl-1,2,4-oxadiazol-5-amine 
• 16219-39-9 N-benzyl-N-(3-phenyl-[1,2,4]oxadiazol-5-yl)-acetamide 
• 16219-38-8 N-methyl-N-(3-phenyl-[1,2,4]oxadiazol-5-yl)-acetamide 
• 18991-15-6 N,N-diethyl-N'-(3-phenyl-[1,2,4]oxadiazol-5-yl)-ethane-1,2-diamine 
• 26899-30-9 N-(3-phenyl-[1,2,4]oxadiazol-5-yl)-benzamide 
• 618-39-3 benzamidin 
• 1456-22-0 3-phenyl-4H-[1,2,4]oxadiazol-5-one 

Relevant articles and documents

Palladium-catalyzed synthesis of 5-amino-1,2,4-oxadiazoles via isocyanide insertion

A convenient and efficient palladium-catalyzed approach has been developed for the synthesis of 5-amino-1,2,4-oxadiazoles from amidoximes and isocyanides. Various 5-amino-1,2,4-oxadiazoles were obtained in moderate to high yields under mild conditions. The key to the success of this strategy involves new C-N bond and C-O bond formation via palladium-catalyzed isocyanide insertion.

SUBSTITUTED PICOLINAMIDE KINASE INHIBITORS

Provided are picolinamide compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

SYNTHESIS AND THERMOLYSIS OF SOME N-HYDROXIMOYL- AND N-HYDRAZONOYLAZOLES

The reactions of nitrile oxides or nitrile imines with pyrazole, imidazole, 1,2,3- and 1,2,4-triazole or tetrazole derivatives yield the appropriate N-hydroximoyl- or N-hydrazonoylazoles.Thermolysis of 1-hydroximoyltetrazoles, depending on the nature of the substituents in the tetrazole ring, yields 1,2,4-oxadiazoles or 5-amino-1,2,4-oxadiazoles upon hydrazoic acid or nitrogen evolution.Under similar conditions, 1-hydrazonoyltetrazoles give 1,2,4-triazoles or 5-amino-1,2,4-triazoles while 2-hydrazonoyltetrazoles decompose to the dihydro-1,2,4,5-tetrazine derivatives.