37031-30-4

Basic information

• Product Name: (4S,5S)-2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DICARBOXYLIC ACID DIMETHYL ESTER
• Synonyms: Dimethyl (4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate, (4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylic acid dimethyl ester;(+)-Dimethyl 2,3-O-isopropylidene-D-tartrate,97%;4S,5S-diethyl 2,2-diMethyl-1,3-dioxolane-4,5-dicarboxylate;Dimethyl (4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylate (4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-dicarboxylic Acid Dimethyl Ester (+)-2,3-O-Isopropylidene-D-tartaric Acid Dimethyl Ester;2,2-Dimethyl-(4S-trans)-1,3-Dioxolane-4,5-dicarboxylic acid dimethyl ester;(+)-DiMethyl 2,3-O-isopropylidene-D-tartarate , GC 97%;(+)-Dimethyl 2,3-O-isopropylidene-D-tartrate 98%;(4S,5S)- 2,2-dimethyl-1,3-Dioxolane-4,5-dicarboxylic acid 4,5-dimethyl ester
• CAS NO: 37031-30-4
• Molecular Formula: C₉H₁₄O₆
• Molecular Weight: 218.2
• Product Categories: Dioxolanes;Esters (Chiral);Synthetic Organic Chemistry;Amino Acids & Derivatives;chiral;Amino Acids 13C, 2H, 15N;Chiral Building Blocks;Dioxanes & Dioxolanes
• Mol File: 37031-30-4.mol

Chemical Properties

• Boiling Point: 80-82 °C0.1 mm Hg(lit.)
• Flash Point: 275 °F
• Appearance: Clear colorless to slightly yellow/Liquid
• Density: 1.19 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00693mmHg at 25°C
• Refractive Index: n20/D 1.439(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol
• BRN: 3548490
• CAS DataBase Reference: (4S,5S)-2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DICARBOXYLIC ACID DIMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5S)-2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DICARBOXYLIC ACID DIMETHYL ESTER(37031-30-4)
• EPA Substance Registry System: (4S,5S)-2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DICARBOXYLIC ACID DIMETHYL ESTER(37031-30-4)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 21
• Hazardous Substances Data: 37031-30-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(4S,5S)-2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DICARBOXYLIC ACID DIMETHYL ESTER is used as a starting material for the synthesis of deuterated 1-deoxy-D-xylose, which is an essential component in the development of pharmaceuticals targeting various diseases.
Used in Peptide Synthesis:
In the field of peptide synthesis, (4S,5S)-2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DICARBOXYLIC ACID DIMETHYL ESTER is used as a key intermediate for the preparation of C-terminal peptide-oxo-aldehydes using Fmoc solid-phase peptide synthesis methodology (SPPS). This application is crucial for the development of novel peptide-based therapeutics.
Used in Organic Synthesis:
(4S,5S)-2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DICARBOXYLIC ACID DIMETHYL ESTER serves as a chiral reagent in organic synthesis, particularly for the preparation of myo-inositol analogs via ring-closing metathesis. This process is vital for the synthesis of complex organic molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Chemical Research:
As a chiral compound with unique structural features, (4S,5S)-2,2-DIMETHYL-1,3-DIOXOLANE-4,5-DICARBOXYLIC ACID DIMETHYL ESTER is also used in chemical research to study the properties and reactivity of chiral molecules, which can lead to the discovery of new synthetic routes and applications in various fields.

InChI:InChI=1/C9H14O6/c1-9(2)14-5(7(10)12-3)6(15-9)8(11)13-4/h5-6H,1-4H3

Upstream product

• 67-56-1 methanol 
• 147-71-7 D-tartaric acid 
• 17081-21-9 1,3-dimethoxy propane 
• 73346-73-3 (4S,5S)-diethyl 2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate 
• 108-86-1 bromobenzene 
• 37031-29-1 (+)-dimethyl-2,3-O-isopropylidene-D-tartrate 
• 13171-64-7 Dimethyl D-tartrate 
• 67-64-1 acetone 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 870279-41-7 (2S,3R)-5-(bis-benzyloxyphosphoryloxymethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid 
• 870279-42-8 dibenzyl (2S,3R)-5-hydroxycarbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl phosphate 
• 206982-20-9 dibenzyl (2S,3R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl phosphate 
• 798554-50-4 (2S,3R)-methyl 5-(bis-benzyloxyphosphoryloxymethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylate 
• 798554-51-5 dibenzyl (2S,3R)-5-carbamoyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl phosphate 
• 137365-16-3 (4S,5S)-2,2-dimethyl-trans-4,5-bis(di(2-naphthyl)hydroxymethyl)-1,3-dioxolane 
• 93222-42-5 (S,S)-taddol 
• 121668-38-0 bis(1-methylethyl) (4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-dicarboxylate 
• 73346-74-4 (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dimethanol 
• 121463-33-0 [(4R,5R)-5-(Hydroxy-diphenyl-methyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-diphenyl-methanol; compound with 1,5-dimethyl-1H-pyridin-2-one 
• 121471-25-8 [(4R,5R)-5-(Hydroxy-diphenyl-methyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-diphenyl-methanol; compound with 1,4-dimethyl-1H-pyridin-2-one 
• 121463-34-1 [(4R,5R)-5-(Hydroxy-diphenyl-methyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-diphenyl-methanol; compound with 4-methoxy-1-methyl-1H-pyridin-2-one 
• 117859-43-5 [(4S,5S)-5-(Hydroxy-diphenyl-methyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-diphenyl-methanol; compound with 7a-methyl-2,3,7,7a-tetrahydro-6H-indene-1,5-dione 
• 117780-11-7 [(4S,5S)-5-(Hydroxy-diphenyl-methyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-diphenyl-methanol; compound with 1,4,5,6,7,7a-hexahydro-inden-2-one 

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