371958-90-6

Basic information

• Product Name: Benzoic acid, 4-[(2-methylpropyl)amino]- (9CI)
• Synonyms: Benzoic acid, 4-[(2-methylpropyl)amino]- (9CI)
• CAS NO: 371958-90-6
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Product Categories: AMINOACID
• Mol File: 371958-90-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoic acid, 4-[(2-methylpropyl)amino]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(2-methylpropyl)amino]- (9CI)(371958-90-6)
• EPA Substance Registry System: Benzoic acid, 4-[(2-methylpropyl)amino]- (9CI)(371958-90-6)

Safety Data

• Hazardous Substances Data: 371958-90-6(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 78-84-2 isobutyraldehyde 

Downstream Products

• 1233518-05-2 4-((((9H-fluoren-9-yl)methoxy)carbonyl)(isobutyl)amino)benzoic acid 
• 1012103-34-2 C₁₅H₂₄N₂O₂ 

Relevant articles and documents

Interfacing native and non-native peptides: using Affimers to recognise α-helix mimicking foldamers

Selection methods are used to identify Affimers that recognise α-helix mimicking N-alkylated aromatic oligoamides thus demonstrating foldamer and natural α-amino acid codes are compatible.

Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

Protein-protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. α-Helix mimetics - small molecules that reproduce the spatial projection of key residues from an α-helix involved in a PPI - are attractive generic templates for development of screening libraries, however library syntheses of α-helix mimetics with diverse functionality are less established. This manuscript describes the automated, microwave assisted solid phase synthesis based on one such scaffold; an N-alkylated oligobenzamide.

N-alkylated oligoamide α-helical proteomimetics

Generic approaches for the design and synthesis of small molecule inhibitors of protein-protein interactions (PPIs) represent a key objective in modern chemical biology. Within this context, the α-helix mediated PPIs have received considerable attention as targets for inhibition using small molecules, foldamers and proteomimetics. This manuscript describes a novel N-alkylated aromatic oligoamide proteomimetic scaffold and its solid-phase synthesis - the first time such an approach has been used for proteomimetics. The utility of these scaffolds as proteomimetics is exemplified through the identification of potent μM inhibitors of the p53-hDM2 helix mediated PPI - a key oncogenic target.