372198-41-9

Basic information

• Product Name: methyl 3-(chlorosulfonyl)-4-methylbenzoate
• Synonyms: methyl 3-(chlorosulfonyl)-4-methylbenzoate;3-(CHLOROSULFONYL)-4-METHYLBENZOIC ACID METHYL ESTER
• CAS NO: 372198-41-9
• Molecular Formula: C₉H₉ClO₄S
• Molecular Weight: 248.69
• Mol File: 372198-41-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 3-(chlorosulfonyl)-4-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(chlorosulfonyl)-4-methylbenzoate(372198-41-9)
• EPA Substance Registry System: methyl 3-(chlorosulfonyl)-4-methylbenzoate(372198-41-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 372198-41-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 3-(chlorosulfonyl)-4-methylbenzoate is used as a building block for the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicine.
Used in Agrochemical Industry:
In the agrochemical industry, methyl 3-(chlorosulfonyl)-4-methylbenzoate is utilized as a precursor in the production of agrochemicals. Its properties make it suitable for the synthesis of compounds that can be used in crop protection and other agricultural applications.
Used in Dye Industry:
Methyl 3-(chlorosulfonyl)-4-methylbenzoate is employed as a building block in the synthesis of dyes. Its chemical structure contributes to the creation of a wide range of dyes with various properties, catering to different industries' needs.
Used in Organic Chemistry as a Reagent:
Methyl 3-(chlorosulfonyl)-4-methylbenzoate is used as a reagent in various organic chemistry reactions, such as esterifications and sulfonation reactions. Its versatility in these reactions makes it a valuable tool for chemists in research and development.

Upstream product

• 67-56-1 methanol 
• 2548-29-0 3-(chlorosulfonyl)-4-methylbenzoic acid 
• 99-94-5 p-Toluic acid 
• 99-75-2 4-methyl-benzoic acid methyl ester 

Downstream Products

• 104224-47-7 methyl 3-mercapto-4-methylbenzoate 
• 104941-65-3 4-methyl-3-(N-(p-tolyl)sulfamoyl)benzoic acid 
• 1101118-46-0 methyl 3-(2-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-1-methylhydrazinylsulfonyl)-4-methylbenzoate 

Relevant articles and documents

Synthesis, 3D-structure and stability analyses of NRPa-308, a new promising anti-cancer agent

We report herein the synthesis of a newly described anti-cancer agent, NRPa-308. This compound antagonizes Neuropilin-1, a multi-partners transmembrane receptor overexpressed in numerous tumors, and thereby validated as promising target in oncology. The p

Inhibitors of Neuropilin and use thereof for the treatment of Neuropilin-related diseases

The present invention relates to a compound of general formula (I), and salts or solvate thereof, for treating a Neuropilin-related disease, disorder or condition; and to a composition, a pharmaceutical composition and a medicament comprising the compound of general formula (I).

INHIBITOR OF NEUROPILIN AND USE THEREOF FOR THE TREATMENT OF NEUROPILIN-RELATED DISEASES

The present invention relates to a compound of general formula (I), and salts or solvate thereof, for treating a Neuropilin-related disease, disorder or condition; and to a composition, a pharmaceutical composition and a medicament comprising the compound of general formula (I).

Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR

Structure-activity relationship studies of the pyrazolo[1,5-a]pyridine class of PI3 kinase inhibitors show that substitution off the hydrazone nitrogen and replacement of the sulfonyl both gave a loss of p110α selectivity, with the exception of an N-hydroxyethyl analogue. Limited substitutions were tolerated around the phenyl ring; in particular the 2,5-substitution pattern was important for PI3 kinase activity. The N-hydroxyethyl compound also showed good inhibition of cell proliferation and inhibition of phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity. It had suitable pharmacokinetics for evaluation in vivo, and showed tumour growth inhibition in two human tumour cell lines in xenograft studies. This work has provided suggestions for the design of more soluble analogues.

PYRAZOLO[1,5-A]PYRIDINES AND THEIR USE IN CANCER THERAPY

Pyrazolo[1,5-a]pyridines are described, including methods for their preparation, and their use as agents or drugs for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.