Carbazates as potent inhibitors of hormone-sensitive lipase
The central role of adipose tissue hormone-sensitive lipase in regulating fatty acid metabolism makes it a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals. The synthesis of a new series of carbazates is presented. Modification of the phenolic 4-position in a series of 1,2,3,4- tetrahydroisoquinoline and morpholine derived carbazates, yielded inhibitors of the catalytic activity of this enzyme with nanomolar potency.
De Jong, Johannes C.,Sorensen, Lotte G.,Tornqvist, Hans,Jacobsen, Poul
Compounds for treating disorders where a decreased level of plasma FFA is desired
The present invention relates to novel compounds, compositions containing them, and their use for treating medical disorders where a decreased level of plasma free fatty acids (FFA) is desired.
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(2008/06/13)
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