Bioorganic and Medicinal Chemistry Letters p. 1741 - 1744 (2004)
Update date:2022-08-03
Topics:
De Jong, Johannes C.
Sorensen, Lotte G.
Tornqvist, Hans
Jacobsen, Poul
The central role of adipose tissue hormone-sensitive lipase in regulating fatty acid metabolism makes it a potential pharmacological target for the prevention of peripheral insulin resistance in obese, prediabetic and diabetic individuals. The synthesis of a new series of carbazates is presented. Modification of the phenolic 4-position in a series of 1,2,3,4- tetrahydroisoquinoline and morpholine derived carbazates, yielded inhibitors of the catalytic activity of this enzyme with nanomolar potency.
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Doi:10.1021/jm00275a037
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