N-(thiazol-2-yl)benzamide derivatives as a new series of supramolecular gelators: Role of methyl functionality and S?O interaction
A new series of N-(thiazol-2-yl) benzamide derivatives were synthesized, characterized and investigated for their gelation behavior with the aim to elucidate the role of methyl functionality and multiple non-covalent interactions on gelation/non-gelation
Modification and biological evaluation of thiazole derivatives as novel inhibitors of metastatic cancer cell migration and invasion
Fascin has recently emerged as a potential therapeutic target, as its expression in cancer cells is closely associated with tumor progression and metastasis. Following the initial discovery of a series of thiazole derivatives that demonstrated potent anti
Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists
A series of diaryl amides was designed and synthesized as novel nonethynyl mGluR5 antagonists. The systematic variation of the pharmacophoric groups led to the identification of a lead compound that demonstrated micromolar affinity for the mGluR5. Further optimization resulted in compounds with improved binding affinities and antagonist profiles, in vitro.
Kulkarni, Santosh S.,Nightingale, Barbara,Dersch, Christina M.,Rothman, Richard B.,Newman, Amy Hauck
p. 3371 - 3375
(2007/10/03)
Syntheses and antimicrobial activities of N-heterocyclic- -mercaptocinnamamides and related compounds.
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Minami,Tomita,Kawaguchi
p. 1716 - 1728
(2007/10/04)
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