37529-67-2Relevant academic research and scientific papers
N-(thiazol-2-yl)benzamide derivatives as a new series of supramolecular gelators: Role of methyl functionality and S?O interaction
Yadav, Priyanka,Ballabh, Amar
, (2020)
A new series of N-(thiazol-2-yl) benzamide derivatives were synthesized, characterized and investigated for their gelation behavior with the aim to elucidate the role of methyl functionality and multiple non-covalent interactions on gelation/non-gelation
Modification and biological evaluation of thiazole derivatives as novel inhibitors of metastatic cancer cell migration and invasion
Zheng, Shilong,Zhong, Qiu,Xi, Yulan,Mottamal, Madhusoodanan,Zhang, Qiang,Schroeder, Richard L.,Sridhar, Jayalakshmi,He, Ling,McFerrin, Harris,Wang, Guangdi
, p. 6653 - 6667 (2014/10/15)
Fascin has recently emerged as a potential therapeutic target, as its expression in cancer cells is closely associated with tumor progression and metastasis. Following the initial discovery of a series of thiazole derivatives that demonstrated potent anti
Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists
Kulkarni, Santosh S.,Nightingale, Barbara,Dersch, Christina M.,Rothman, Richard B.,Newman, Amy Hauck
, p. 3371 - 3375 (2007/10/03)
A series of diaryl amides was designed and synthesized as novel nonethynyl mGluR5 antagonists. The systematic variation of the pharmacophoric groups led to the identification of a lead compound that demonstrated micromolar affinity for the mGluR5. Further optimization resulted in compounds with improved binding affinities and antagonist profiles, in vitro.
