38028-67-0

Basic information

• Product Name: 2-Ethoxypyrazine
• Synonyms: 3-Ethoxypyridazine;ethoxy pyrazine;Pyrazine, ethoxy-;2-ETHOXYPYRAZINE;2-Ethoxy
• CAS NO: 38028-67-0
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• EINECS: 253-750-8
• Product Categories: Pyrazines;Alkoxypyrazines;pyrazine Flavor
• Mol File: 38028-67-0.mol

Chemical Properties

• Boiling Point: 92 °C / 90mmHg
• Flash Point: 59.8oC
• Appearance: /
• Density: 1.07
• Vapor Pressure: 1.89mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.68±0.10(Predicted)
• CAS DataBase Reference: 2-Ethoxypyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethoxypyrazine(38028-67-0)
• EPA Substance Registry System: 2-Ethoxypyrazine(38028-67-0)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 38028-67-0(Hazardous Substances Data)

Usage

Uses

Used in the Food and Beverage Industry:
2-Ethoxypyrazine is used as a flavoring agent for its distinctive earthy, green, and musty notes, enhancing the taste profiles of coffee, chocolate, and various other food products.
Used in the Fragrance Industry:
In the realm of perfumery, 2-Ethoxypyrazine is utilized as a component to impart a green, earthy scent to perfumes and colognes, contributing to their unique and complex aromas.
Due to its potent odor, 2-Ethoxypyrazine is employed in minute quantities, ensuring that it does not overpower the other ingredients in the products it is used in, while still significantly enriching their sensory characteristics.

InChI:InChI=1/C6H8N2O/c1-2-9-6-5-7-3-4-8-6/h3-5H,2H2,1H3

Upstream product

• 14508-49-7 2-chloropyrazin 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 

Downstream Products

• 6270-63-9 pyrazin-2(1H)-one 

Relevant articles and documents

Efficient nucleophilic substitution reactions of pyrimidyl and pyrazyl halides with nucleophiles under focused microwave irradiation

Rapid nucleophilic displacement reactions of 2-chloropyrimidine, 2-bromopyrimidine, 5-bromopyrimidine and chloropyrazine with nucleophiles under microwave irradiation was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to the classical heating processes.

The Mechanism of Thermal Eliminations. Part 18. Relative Rates of Pyrolysis of 2-Ethoxypyrazine, 3-Ethoxypyridazine, 2-and 4-Ethoxypyrimidine, 3-Chloro-6-ethoxypyridazine, and 2-Chloro-4-ethoxypyrimidine : the Effect of the Aza 'Substituent' and ?-Bond Order on the Elimination Rate

A kinetic study has been made of the first-order thermal decomposition of the title compounds into ethylene and the corresponding aza-substituted pyridines, between 650 and 713 K.The relative elimination rates at 650 K are (2-ethoxypyridine = 1): 0.545, 10.0, 1.03, 1.12, 9.68, and 3.28, respectively.The electronic effects of the aza 'substituent' are small, and a more important factor appears to be the C-N ?-bond order; this latter accounts for the high reactivity of the pyridazines.The effects of the chloro substituent and of the aza 'substituent' are explicable in terms of a balance between electron withdrawal from the C-O bond (producing deactivation) and from the nitrogen involved in the cyclic transition state (producing deactivation).The effects of the chloro substituents confirm that the most important step of the reaction is breaking of the C-O bond.The statistically corrected rate (per ring nitrogen) of 2-ethoxypyrimidine is unexpectedly low.This may reflect difficulty in achieving the coplanar transition state in which the lone pairs in the s-orbitals of oxygen and the nitrogen not involved in the elimination are brought into close proximity.