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4-FLUOROBENZYLMAGNESIUM CHLORIDE 0.25M is a chemical compound that consists of a 0.25M solution of 4-Fluorobenzylmagnesium chloride. It is an important reagent in organic chemistry, characterized by its mild and selective nucleophilic properties, which are instrumental in the formation of carbon-carbon and carbon-heteroatom bonds. This reagent is particularly useful in Grignard reactions for the introduction of the 4-Fluorobenzyl group into organic molecules, and it plays a significant role in the synthesis of pharmaceutical intermediates and fine chemicals. The 0.25M concentration denotes the molarity of the solution, reflecting the number of moles of the compound dissolved in one liter of solvent.

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  • 38046-82-1 Structure
  • Basic information

    1. Product Name: 4-FLUOROBENZYLMAGNESIUM CHLORIDE 0.25M&
    2. Synonyms: 6-Methoxy-2-naphthylmagnesium bromide solution 0.5 in THF;6-Methoxy-2-naphthylmagnesium bromide, 0.5M solution in THF, AcroSeal;6-Methoxy-2-naphthylMagnesiuM broMide, 0.5M in THF;6-Methoxy-2-naphthylMagnesiuM broMide, 0.5 M solution in THF, SpcSeal;6-Methoxy-2-naphthylmagnesium bromide solution 0.5 M in THF;magnesium,6-methoxy-2H-naphthalen-2-ide,bromide;4-FLUOROBENZYLMAGNESIUM CHLORIDE 0.25M&;6-METHOXY-2-NAPHTHYLMAGNESIUM BROMIDE, 0.5 M SOLUTION IN THF
    3. CAS NO:38046-82-1
    4. Molecular Formula: C11H9BrMgO
    5. Molecular Weight: 261.4
    6. EINECS: N/A
    7. Product Categories: Aryl;Grignard Reagents;Organometallic Reagents
    8. Mol File: 38046-82-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 35 °C
    3. Flash Point: -13 °F
    4. Appearance: /
    5. Density: 0.966 g/mL at 25 °C
    6. Vapor Pressure: 0.0104mmHg at 25°C
    7. Refractive Index: N/A
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-FLUOROBENZYLMAGNESIUM CHLORIDE 0.25M&(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-FLUOROBENZYLMAGNESIUM CHLORIDE 0.25M&(38046-82-1)
    12. EPA Substance Registry System: 4-FLUOROBENZYLMAGNESIUM CHLORIDE 0.25M&(38046-82-1)
  • Safety Data

    1. Hazard Codes: F+,C,F,Xn
    2. Statements: 12-14-19-22-34-67-11-40-36/37
    3. Safety Statements: 9-16-29-33-45-36/37-26
    4. RIDADR: UN 2924 3/PG 2
    5. WGK Germany: 1
    6. RTECS:
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 38046-82-1(Hazardous Substances Data)

38046-82-1 Usage

Uses

Used in Organic Synthesis:
4-FLUOROBENZYLMAGNESIUM CHLORIDE 0.25M is used as a nucleophile for the formation of carbon-carbon and carbon-heteroatom bonds in organic synthesis. Its mild and selective nature makes it a preferred reagent for creating these bonds, which are crucial in the construction of complex organic molecules.
Used in Grignard Reactions:
In the field of Grignard reactions, 4-FLUOROBENZYLMAGNESIUM CHLORIDE 0.25M is used as a reagent to introduce the 4-Fluorobenzyl group into organic molecules. This introduction is vital for the synthesis of a variety of organic compounds, including those with potential applications in pharmaceuticals and materials science.
Used in Pharmaceutical Industry:
4-FLUOROBENZYLMAGNESIUM CHLORIDE 0.25M is used as a reagent for the preparation of pharmaceutical intermediates. Its ability to form specific carbon-carbon and carbon-heteroatom bonds makes it a valuable tool in the synthesis of complex drug molecules, contributing to the development of new medications and therapies.
Used in Fine Chemicals Industry:
In the fine chemicals industry, 4-FLUOROBENZYLMAGNESIUM CHLORIDE 0.25M is utilized for the synthesis of high-purity specialty chemicals. Its selective reactivity allows for the precise construction of molecular structures required in fragrances, dyes, and other high-value chemical products.

Check Digit Verification of cas no

The CAS Registry Mumber 38046-82-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,0,4 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 38046-82:
(7*3)+(6*8)+(5*0)+(4*4)+(3*6)+(2*8)+(1*2)=121
121 % 10 = 1
So 38046-82-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H9O.BrH.Mg/c1-12-11-7-6-9-4-2-3-5-10(9)8-11;;/h3-8H,1H3;1H;/q-1;;+2/p-1

38046-82-1 Well-known Company Product Price

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  • Aldrich

  • (646946)  6-Methoxy-2-naphthylmagnesiumbromidesolution  0.5 M in THF

  • 38046-82-1

  • 646946-50ML

  • 2,988.18CNY

  • Detail

38046-82-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name magnesium,6-methoxy-2H-naphthalen-2-ide,bromide

1.2 Other means of identification

Product number -
Other names 6-Methoxy-2-naphthylmagnesium bromide solution

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38046-82-1 SDS

38046-82-1Relevant articles and documents

Naphthylene derivatives as cytochrome P450 inhibitors

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Page/Page column 43, (2010/02/15)

Compounds of the formula and pharmaceutically acceptable salts thereof, wherein n1, n2, n3, n4, G1, Q1, Z, R1, R2, R3, R4a, R4b, R5a, and R5b are defined he

NAPHTHYLENE DERIVATIVES AS CYTOCHROME P450 INHIBITORS

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Page/Page column 109, (2010/02/10)

Compounds of the formula (I); and pharmaceutically acceptable salts thereof, wherein n1, n2, n3, n4, G 1,Q1, Z, R1, R2, R3, R4a, R4b, R5a, and R5b are defined herein, inhibit the cytochrome P450RAI enzyme and are useful for the treatment and/or prevention of various diseases and conditions which respond to treatment by retinoids and by naturally occurring retinoic acid.

Optically active 1-(6-methoxy-2-naphthyl)-2-(alkoxycarbonyl) amino-1-propanone, its derivatives and their halo analogs and the methods for their manufacture

-

, (2008/06/13)

A manufacturing method is described for the preparation of optically active 1-(6-methoxy-2-naphthyl)-2-(alkoxycarbonyl)amino-1-propanone, its derivatives and their halo analogs. The optically active 1-(6-methoxy-2-naphthyl)-2-(alkoxycarbonyl)amino-1-propanone, its derivatives and their halo analogs are useful intermediates in the preparation of 2-(6-methoxy-2-naphthyl)propionic acid, which is useful as pharmaceutical, e.g. antiinflammatory, analgesic and anti-pyretic agents.

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