380922-37-2

Basic information

• Product Name: 1-Methylindoline-5-carboxylic acid 97%
• Synonyms: 1-Methylindoline-5-carboxylic acid 97%;1-METHYLINDOLINE-5-CARBOXYLIC ACID;2,3-Dihydro-1-methyl-1H-indole-5-carboxylic acid, 5-Carboxy-1-methylindoline
• CAS NO: 380922-37-2
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Mol File: 380922-37-2.mol

Chemical Properties

• Melting Point: 220.5-230°C
• Boiling Point: 375.6°Cat760mmHg
• Flash Point: 180.9°C
• Appearance: /
• Density: 1.246g/cm³
• Vapor Pressure: 2.62E-06mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 1-Methylindoline-5-carboxylic acid 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methylindoline-5-carboxylic acid 97%(380922-37-2)
• EPA Substance Registry System: 1-Methylindoline-5-carboxylic acid 97%(380922-37-2)

Safety Data

• Hazardous Substances Data: 380922-37-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-Methylindoline-5-carboxylic acid 97% is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Production:
1-Methylindoline-5-carboxylic acid 97% is utilized as a building block in the creation of agrochemicals, such as pesticides and herbicides, due to its reactivity and compatibility with other chemical components, enhancing the effectiveness of these products in agricultural applications.
Used in Organic Synthesis Research:
In the field of organic synthesis research, 1-Methylindoline-5-carboxylic acid 97% serves as a valuable compound for exploring new reaction pathways and developing innovative synthetic methods, thanks to its unique structural features and high purity.
Used in Industrial Chemical Formulations:
1-Methylindoline-5-carboxylic acid 97% is employed in the formulation of various industrial chemicals, where its stability and purity ensure the consistency and performance of the final products in diverse applications.

InChI:InChI=1/C10H11NO2/c1-11-5-4-7-6-8(10(12)13)2-3-9(7)11/h2-3,6H,4-5H2,1H3,(H,12,13)

Upstream product

• 186129-25-9 1-methyl-1H-indole-5-carboxylic acid 
• 60082-02-2 1-methylindoline-5-carboxaldehyde 
• 50-00-0 formaldehyd 
• 1670-81-1 1H-Indole-5-carboxylic acid 

Downstream Products

• 256935-66-7 1-methyl-2, 3-dihydro-indole-5-carboxylic acid (N-[2-hydroxy-2-(3,4,5-trimethoxyphenyl) ethyl])amide 

Relevant articles and documents

HCV PROTEASE INHIBITORS

This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.

COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV

The invention aims to provide a dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. The invention is directed to a compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or -COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1 and R2, together with a carbon atom to which they are bound, represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents -CONR6-, -CO- or -NR6CO-, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents -(CH2)m- whereupon m is an integer of 1 to 3, -CH2OCH2-, or -SCH2-, n is an integer of 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.

New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models

During a screen for compounds that could inhibit cell proliferation, a series of new tubulin-binding compounds was identified with the discovery of oxadiazoline 1 (A-105972). This compound showed good cytotoxic activity against non-multi-drug-resistant and multi-drug-resistant cancer cell lines, but its utility in vivo was limited by a short half-life. Medicinal chemistry efforts led to the discovery of indolyloxazoline 22g (A-259745), which maintained all of the in vitro activity seen with oxadiazoline 1, but also demonstrated a better pharmacokinetic profile, and dose-dependent in vivo activity. Over a 28 day study, indolyloxazoline 22g increased the life span of tumor-implanted mice by up to a factor of 3 upon oral dosing. This compound, and others of its structural class, may prove to be useful in the development of new chemotherapeutic agents to treat human cancers.