1-Methylindoline-5-carboxylic acid 97%

Base Information

• Chemical Name: 1-Methylindoline-5-carboxylic acid 97%
• CAS No.: 380922-37-2
• Molecular Formula: C10H11 N O2
• Molecular Weight: 177.2
• Hs Code.: 2933990090
• Mol file: 380922-37-2.mol

Synonyms:1-Methylindoline-5-carboxylic acid 97%;1-METHYLINDOLINE-5-CARBOXYLIC ACID

Chemical Property of 1-Methylindoline-5-carboxylic acid 97%

Chemical Property:

• Vapor Pressure: 2.62E-06mmHg at 25°C
• Melting Point: 220.5-230°C
• Refractive Index: 1.606
• Boiling Point: 375.6°Cat760mmHg
• Flash Point: 180.9°C
• PSA: 40.54000
• Density: 1.246g/cm³
• LogP: 1.44210

Purity/Quality:

97% ^*data from raw suppliers

1-Methylindoline-5-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methylindoline-5-carboxylic acid 97%

There total 3 articles about 1-Methylindoline-5-carboxylic acid 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-methyl-1H-indole-5-carboxylic acid (186129-25-9) → N-methylindoline-5-carboxylic acid (380922-37-2)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 20 ℃; for 0.333333h;

Reference yield: 74.0%

1-methylindoline-5-carboxaldehyde (60082-02-2) → N-methylindoline-5-carboxylic acid (380922-37-2)

Guidance literature:

With potassium hydroxide; sodium hydroxide; In neat (no solvent); Heating;

DOI:10.1080/00304948.2017.1260396

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1H-Indole-5-carboxylic acid (1670-81-1,142396-03-0) → N-methylindoline-5-carboxylic acid (380922-37-2)

Guidance literature:

With N-[2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]amide; sodium cyanoborohydride; acetic acid; for 18h;

DOI:10.1021/jm010231w

upstream raw materials:

formaldehyd

1H-Indole-5-carboxylic acid

1-methyl-1H-indole-5-carboxylic acid

1-methylindoline-5-carboxaldehyde

Downstream raw materials:

1-methyl-2, 3-dihydro-indole-5-carboxylic acid (N-[2-hydroxy-2-(3,4,5-trimethoxyphenyl) ethyl])amide