60082-02-2

Basic information

• Product Name: 1-Methylindoline-5-carboxaldehyde 97%
• Synonyms: 1-Methylindoline-5-carboxaldehyde 97%;1-Methylindoline-5-carboxaldehyde;2,3-Dihydro-1-methyl-1H-indole-5-carboxaldehyde;2,3-Dihydro-1-methyl-1H-indole-5-carboxaldehyde, 5-Formyl-1-methylindoline;1-methyl-5-Indolinecarboxaldehyde;1-Methylindoline-5-carboxaldehyde97%;1-Methyl-2,3-dihydro-1H-indole-5-carbaldehyde
• CAS NO: 60082-02-2
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.21
• Mol File: 60082-02-2.mol

Chemical Properties

• Boiling Point: 324.2 °C at 760 mmHg
• Flash Point: 137.3 °C
• Appearance: /
• Density: 1.141 g/cm³
• Vapor Pressure: 0.000249mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 1-Methylindoline-5-carboxaldehyde 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methylindoline-5-carboxaldehyde 97%(60082-02-2)
• EPA Substance Registry System: 1-Methylindoline-5-carboxaldehyde 97%(60082-02-2)

Safety Data

• Hazardous Substances Data: 60082-02-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Methylindoline-5-carboxaldehyde 97% is used as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medications.
Used in Dye Industry:
1-Methylindoline-5-carboxaldehyde 97% is utilized as an intermediate in the production of dyes, playing a crucial role in the creation of colorants for various applications.
Used in Flavor and Fragrance Industry:
1-Methylindoline-5-carboxaldehyde 97% is used as a flavor and fragrance ingredient, adding unique scents and tastes to various products.
Used in Agricultural Chemicals Production:
1-Methylindoline-5-carboxaldehyde 97% is employed in the production of agricultural chemicals, helping to develop effective solutions for crop protection and enhancement.
Used in Organic Chemistry as a Reagent:
1-Methylindoline-5-carboxaldehyde 97% serves as a reagent in organic chemistry reactions, facilitating important processes and transformations in the synthesis of various organic compounds.

InChI:InChI=1/C10H11NO/c1-11-5-4-9-6-8(7-12)2-3-10(9)11/h2-3,6-7H,4-5H2,1H3

Upstream product

• 824-21-5 N-methylindoline 
• 68-12-2 N,N-dimethyl-formamide 
• 496-15-1 1-indoline 
• 2861-59-8 N-formylindoline 

Downstream Products

• 124548-84-1 1-methyl-5-indoline 
• 91459-39-1 1-Methyl-5-(trans-2-phenyl-1-ethenyl)indole 
• 124548-87-4 4-[(E)-2-(1-Methyl-2,3-dihydro-1H-indol-5-yl)-vinyl]-phenol 
• 124567-97-1 1-methyl-5-indole 
• 124548-89-6 1-methyl-5-indoline 
• 124548-91-0 1-methyl-5-indole 
• 90923-75-4 1-methyl-1H-indole-5-carboxaldehyde 
• 380922-37-2 N-methylindoline-5-carboxylic acid 

Relevant articles and documents

Synthesis, Structure, and Properties of Amino-Substituted Benzhydrylium Ions – A Link between Ordinary Carbocations and Neutral Electrophiles

Optimized synthetic procedures for the straightforward access to eleven amino-substituted diarylmethylium tetrafluoroborates are described. These benzhydrylium ions cover a range of seven orders of magnitude in electrophilicity and provide a link between ordinary carbocations and neutral electrophiles. Five of these highly stabilized benzhydrylium tetrafluoroborates were characterized by single-crystal X-ray crystallography. While the experimentally determined bond lengths and angles in the solid state perfectly agree with those calculated by DFT methods for the gas phase and aqueous solution, crystal packing accounts for large differences in the twist angles of the aryl groups found in the solid state as compared to calculated structures.

Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification

The acetylcholine binding protein (AChBP) is considered an analogue for the ligand-binding domain of neuronal nicotinic acetylcholine receptors (nAChRs). Its stability and solubility in aqueous buffer allowed the development of an online bioaffinity analysis system. For this, a tracer ligand which displays enhanced fluorescence in the binding pocket of AChBP was identified from a concise series of synthetic benzylidene anabaseines. Evaluation and optimization of the bioaffinity assay was performed in a convenient microplate reader format and subsequently transferred to the online format. The high reproducibility has the prospect of estimating the affinities of ligands from an in-house drug discovery library injected in one known concentration. Furthermore, the online bioaffinity analysis system could also be applied to mixture analysis by using gradient HPLC. This led to the possibility of affinity ranking of ligands in mixtures with parallel high-resolution mass spectrometry for compound identification.