- Efficiency and stability of spectral sensitization of boron-doped-diamond electrodes through covalent anchoring of a donor-acceptor organic chromophore (P1)
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A novel procedure is developed for chemical modification of H-terminated B-doped diamond surfaces with a donor-π-bridge-acceptor molecule (P1). A cathodic photocurrent near 1 μA cm-2 flows under 1 Sun (AM 1.5) illumination at the interface betw
- Krysova, Hana,Barton, Jan,Petrak, Vaclav,Jurok, Radek,Kuchar, Martin,Cigler, Petr,Kavan, Ladislav
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Read Online
- Convenient synthesis of (E)-5-aminoallyl-2′-deoxycytidine and some related derivatives
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Preparation via the Heck reaction of 5-(E)-(3-trifluoroacetamidoallyl)- 2′-deoxycytidine (3a) and some N4-formamidine protected derivatives is reported. Difficulties with coupling N-allyl-trifluoroacetamide to 5-iodo-2′-deoxycytidine were overcome by using Pd2(dba) 3 as catalyst and temporary dimethylformamidine protection of the N4-amine of the nucleoside. Compound 3a was isolated with 60% overall yield by crystallization.
- Reddington, Mark V.,Cunninghan-Bryant, Daniel
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Read Online
- Electrochemical approach to trifluoroacetamide synthesis from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) catalyzed by B12complex
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One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
- Moniruzzaman, Mohammad,Yano, Yoshio,Ono, Toshikazu,Hisaeda, Yoshio,Shimakoshi, Hisashi
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- Oxidative Amide Coupling from Functionally Diverse Alcohols and Amines Using Aerobic Copper/Nitroxyl Catalysis
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The aerobic Cu/ABNO catalyzed oxidative coupling of alcohols and amines is highlighted in the synthesis of amide bonds in diverse drug-like molecules (ABNO=9-azabicyclo[3.3.1]nonane N-oxyl). The robust method leverages the privileged reactivity of alcohol
- Piszel, Paige E.,Vasilopoulos, Aristidis,Stahl, Shannon S.
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supporting information
p. 12211 - 12215
(2019/07/31)
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- Anion Receptor, Electrolyte Containing the Anion Receptor and Lithium Ion Battery and Lithium Ion Capacitor Using the Electrolyte
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The present invention relates to a novel anion acceptor having a high cation transport rate and improved lifespan, an electrolyte containing the same, and a lithium ion battery and a lithium ion capacitor manufactured using the electrolyte and, more specifically, to a compound represented by chemical formula 1. In the chemical formula 1, n is an integer from 1 to 50, and X is one or more selected from the group consisting of -NR_1R_2, -NR_3R_4, -Ph(-(m)-R_5), and -O-(CH_2CH_2O)_y-CH_3.COPYRIGHT KIPO 2018
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Paragraph 0052-0054
(2018/09/30)
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- Transition metal-free intermolecular a-C-H amination of ethers at room temperature
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We describe a new method for the intermolecular amination of the α-C-H bonds of ethers. A hypervalent iodine reagent was used as oxidant to enable the amination of cyclic and acyclic alkyl ethers with a wide range of amides, imides, and amines. The amination occurred at room temperature and without a transition metal catalyst. The method could be used to synthesize the anti-cancer prodrug Tegafur and its analogues.
- Buslov, Ivan,Hu, Xile
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supporting information
p. 3325 - 3330
(2015/02/02)
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- Iodine(III)-promoted synthesis of oxazolines from N-allylamides
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PhI(OAc)2 (activated by BF3·OEt2) has been used to promote the oxidative cyclization of N-allylamides to give oxazolines. The reaction products are formed in high yield and, when a branched allylic amine is used, high diastereoselectivity. Initial mechanistic experiments suggest that the final C-O bond is formed from a reactive tight ion pair, rather than a neutral external nucleophile.
- Moon, Nicholas G.,Harned, Andrew M.
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supporting information
p. 2960 - 2963
(2013/06/27)
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- Substrate-directable heck reactions with arenediazonium salts. The regio- and stereoselective arylation of allylamine derivatives and applications in the synthesis of naftifine and abamines
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The palladium-catalyzed, substrate-directable Heck-Matsuda reaction of allylamine derivatives with arenediazonium salts is reported. The reaction proceeds under mild conditions, with excellent regio- and stereochemical control as a function of coordinating groups present in the allylamine substrate. The distance between the olefin moiety and the car-bonylic system seems to play a key role regarding the regiocontrol. The method presents itself as robust, as simple to carry out, and with wide synthetic scope concerning the allylic substrates and the type of arenediazonium employed. The synthetic potential of the method is illustrated by the short total syntheses of the bioactive compounds naftifine, abamine, and abamine SG.
- Prediger, Patricia,Barbosa, Lais Ferreira,Genisson, Yves,Correia, Carlos Roque Duarte
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experimental part
p. 7737 - 7749
(2011/12/01)
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- Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine
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We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.
- Kim, Joong-Gon,Jang, Doo Ok
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scheme or table
p. 683 - 685
(2010/04/02)
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- COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
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Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
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Page/Page column 178
(2010/05/13)
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- Convenient one-pot synthesis of N-substituted 3-trifluoroacetyl pyrroles
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A new one-pot strategy for the synthesis of a series of new N-substituted 3-trifluoroacetyl pyrroles is presented. These compounds were obtained by the reaction of 3-trifluoroacetyl-4,5-dihydrofuran with primary amines, which generated 1,1,1-trifluoro-3-(2-hydroxyethyl)-4-alkylaminobut-3-en-2-one intermediates. In most cases these intermediates were not stable enough to be isolated. Thus, in the same reaction vessel they were directly submitted to oxidation with PCC (Corey's reagent) to furnish 1,1,1-trifluoro-3-(2-ethanal)-4- alkylaminobut-3-en-2-ones, which under reflux underwent intramolecular cyclization to give the desired N-substituted 3-trifluoroacetyl pyrroles, in moderate yields. All of these pyrroles were tested against pan-susceptible Mycobacterium tuberculosis H37Rv and clinical isolates INH- and RMP-resistant strain and some of these compounds showed significant in vitro antimicrobial activity. Georg Thieme Verlag Stuttgart.
- Zanatta, Nilo,Wouters, Ana D.,Fantinel, Leonardo,Da Silva, Fabio M.,Barichello, Rosemário,Da Silva, Pedro E. A.,Ramos, Daniela F.,Bonacorso, Helio G.,Martins, Marcos A. P.
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experimental part
p. 755 - 758
(2009/07/18)
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- ALKOXY COMPOUNDS FOR DISEASE TREATMENT
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The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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Page/Page column 157
(2009/05/29)
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- A SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELL NUCLEI
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A novel class of oligomeric compounds designed for forming conjugates with biologically active substances and delivering these substances to a desired bodily target are disclosed. Nove1 conjugates of biologically active moities and such oligomeric compounds, pharmaceutical compositions containing such conjugates, and uses thereof as delivery systems for delivering the biologically active substances to a desired target are further disclosed. Processes of preparing the conjugates and the oligomeric compounds and novel intermediates designed for and used in these processes are also disclosed.
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Page/Page column 65
(2008/06/13)
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- Ketone-DNA: A versatile postsynthetic DNA decoration platform
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matrix presented A general strategy for the functional diversification of DNA oligonucleotides under physiological conditions was developed. We describe the synthesis of DNA molecules bearing ketone ports (ketone-DNA) and the efficient postsynthetic decor
- Dey, Subhakar,Sheppard, Terry L.
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p. 3983 - 3986
(2007/10/03)
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- 3-aryl-2-isoxazolines as antiinflammatory agents
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This invention relates to 3-aryl-2-isoxazoline compounds which are selective inhibitors of phosphodiesterase type IV (PDEIV). The 3-aryl-2-isoxazolines are useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulm
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- New Routes to Heterocycles via Sulphenylation of Unsaturated Amides
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The reaction of manganese(III) acetate with diphenyl disulphide in dichloromethane-trifluoroacetic acid in the presence of N-allylacetamide, followed by hydrolysis, affords a vicinal hydroxy sulphide.Similarly, addition to N-allyltrifluoroacetamide affords hydroxy sulphide adducts, but with different regioselectivity.N-Allylbenzamide and other unsaturated benzamides under similar conditions give cyclic products, 4,5-dihydro-1,3-oxazoles.Homoallylic amides give 5,6-dihydro-4H-1,3-oxazines.Amides derived from pent-4-enylamine give substituted pyrrolidines by cyclisation through nitrogen, but N-hex-5-enylbenzamide gives only an acyclic adduct.Unsaturated carboxylic acids and unsaturated carboxamides are transformed in good yield into lactones under similar conditions.
- Samii, Zakaria K. M. Abd El,Ashmawy, Mohamed I. Al,Mellor, John M.
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p. 2517 - 2522
(2007/10/02)
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- Reactions of the Readily Accessible Electrophile, Trifluoroacetyl Triflate: A Very Reactive Agent for Trifluoroacetylations at Oxygen, Nitrogen, Carbon, or Halogen Centers
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Trifluoroacetyl triflate (TFAT) is readily prepared in 82percent yield by the dehydration (phosphorus pentoxide) of a 2:1 mixture of trifluoroacetic acid and trifluoromethanesulfonic (triflic) acid.Reactions of this highly electrophilic trifluoroacetylating reagent with alcohols, ketones, ethers, amines, and pyridines give esters, enol esters, ether cleavage, amides, and acylpyridinium ions, respectively.Reactions with ionic or easily ionizable alkyl halides give the very volatile trifluoroacetyl halides and the ionic triflate.Triphenylmethyl chloride, for example, is quantitatively converted to triphenylcarbenium triflate in a very convenient synthetic procedure.Trifluoroacetyl triflate is used in the synthesis of the first member of a new class of pyrylium salts, 2,6-dimethoxypyrylium triflate.
- Forbus, T. R.,Taylor, S. L.,Martin, J. C.
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p. 4156 - 4159
(2007/10/02)
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- REGIOSELECIVE HYDROXYSULPHENYLATION OF DERIVATIVES OF ALLYLIC ALCOHOLS AND AMINES
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Reaction of manganic acetate with diphenyldisulphide in dichloromethane-trifluoroacetic acid in the presence of allylic esters or amides of allylamine gives trifluoroacetoxysulphides and hence by ready hydrolysis vicinal hydroxysulphides.The regiochemical outcome can be controlled by selection of either an acetyl- or trifluoroacetyl derivative.
- Samii, Zakaria K M Abd El,Ashmawy, Mohamed I Al,Mellor, John M
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p. 5289 - 5292
(2007/10/02)
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