383-65-3

Usage

Uses

Used in Pharmaceutical Industry:
N-Allyl-2,2,2-trifluoroacetamide is used as an intermediate in the synthesis of pharmaceuticals for its ability to participate in key chemical reactions that facilitate the creation of medicinal compounds. Its reactivity and unique properties contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, N-Allyl-2,2,2-trifluoroacetamide is employed as an intermediate in the production of agrochemicals, leveraging its reactive nature to form compounds that can be used in pesticides, herbicides, and other agricultural chemicals to enhance crop protection and yield.
Used in Organic Synthesis:
N-Allyl-2,2,2-trifluoroacetamide is used as a building block in organic synthesis for its versatility in forming complex organic molecules. It serves as a starting material for the preparation of a variety of functionalized compounds, contributing to the advancement of organic chemistry and the discovery of new chemical entities with diverse applications.

InChI:InChI=1/C5H6F3NO/c1-2-3-9-4(10)5(6,7)8/h2H,1,3H2,(H,9,10)

Upstream product

• 107-11-9 1-amino-2-propene 
• 407-25-0 trifluoroacetic anhydride 
• 68602-57-3 trifluoroacetyl triflate 
• 383-63-1 ethyl trifluoroacetate, 
• 109317-75-1 4-trifluoroacetyl-2,3-dihydrofuran 
• 76-05-1 trifluoroacetic acid 
• 815-06-5 N-methyl-2,2,2-trifluoroacetamide 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 75-89-8 2,2,2-trifluoroethanol 
• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 

Downstream Products

• 25222-21-3 2,2,2-Trifluoro-N-(1,4,5,6,7,7-hexafluoro-bicyclo[2.2.1]hept-5-en-2-ylmethyl)-acetamide 
• 110210-98-5 N-(2-hydroxy-3-phenylthiopropyl)trifluoroacetamide 
• 110210-99-6 N-(3-hydroxy-2-phenylthiopropyl)trifluoroacetamide 
• 115794-55-3 5-(3''-trifluoroacetamidoallyl)-2'-deoxyuridine 
• 462117-95-9 2-(2,6-Difluorophenyl)-4-(4-(5-(trifluoroacetamidomethyl)isoxazolin-3-yl) phenyl)oxazoline 
• 869222-68-4 N-((E)-3-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)allyl)-2,2,2-trifluoroacetamide 
• 7446-09-5 sulfur dioxide 
• 1222166-03-1 (E)-2,2,2-trifluoro-N-(3-(3-nitrophenyl)allyl)acetamide 
• 1185180-07-7 (RS) (E) 2-trifluoroacetyl-1,2,3,4-tetrahydro-6,7-dimethoxy-1-[4',5'-dimethoxy-2'-(3-trifluoroacetyl-1-propenyl)phenyl]methylisoquinoline 
• 1334031-91-2 (E)-2,2,2-trifluoro-N-(3-(4-methoxyphenyl)allyl)acetamide 
• 1215076-89-3 C₁₈H₂₂F₃NOS 
• 1215077-79-4 (E)-N-(3-(3-(butylsulfonyl)phenyl)allyl)-2,2,2-trifluoroacetamide 
• 1215077-11-4 (E)-N-(3-(3-(2-ethyl-2-hydroxybutylthio)phenyl)allyl)-2,2,2-trifluoroacetamide 
• 1215077-68-1 (E)-N-(3-(3-(butylthio)phenyl)allyl)-2,2,2-trifluoroacetamide 

Relevant academic research and scientific papers

Efficiency and stability of spectral sensitization of boron-doped-diamond electrodes through covalent anchoring of a donor-acceptor organic chromophore (P1)

A novel procedure is developed for chemical modification of H-terminated B-doped diamond surfaces with a donor-π-bridge-acceptor molecule (P1). A cathodic photocurrent near 1 μA cm-2 flows under 1 Sun (AM 1.5) illumination at the interface betw

Convenient synthesis of (E)-5-aminoallyl-2′-deoxycytidine and some related derivatives

Preparation via the Heck reaction of 5-(E)-(3-trifluoroacetamidoallyl)- 2′-deoxycytidine (3a) and some N4-formamidine protected derivatives is reported. Difficulties with coupling N-allyl-trifluoroacetamide to 5-iodo-2′-deoxycytidine were overcome by using Pd2(dba) 3 as catalyst and temporary dimethylformamidine protection of the N4-amine of the nucleoside. Compound 3a was isolated with 60% overall yield by crystallization.

Electrochemical approach to trifluoroacetamide synthesis from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) catalyzed by B12complex

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.

Oxidative Amide Coupling from Functionally Diverse Alcohols and Amines Using Aerobic Copper/Nitroxyl Catalysis

The aerobic Cu/ABNO catalyzed oxidative coupling of alcohols and amines is highlighted in the synthesis of amide bonds in diverse drug-like molecules (ABNO=9-azabicyclo[3.3.1]nonane N-oxyl). The robust method leverages the privileged reactivity of alcohol

Anion Receptor, Electrolyte Containing the Anion Receptor and Lithium Ion Battery and Lithium Ion Capacitor Using the Electrolyte

The present invention relates to a novel anion acceptor having a high cation transport rate and improved lifespan, an electrolyte containing the same, and a lithium ion battery and a lithium ion capacitor manufactured using the electrolyte and, more specifically, to a compound represented by chemical formula 1. In the chemical formula 1, n is an integer from 1 to 50, and X is one or more selected from the group consisting of -NR_1R_2, -NR_3R_4, -Ph(-(m)-R_5), and -O-(CH_2CH_2O)_y-CH_3.COPYRIGHT KIPO 2018

Transition metal-free intermolecular a-C-H amination of ethers at room temperature

We describe a new method for the intermolecular amination of the α-C-H bonds of ethers. A hypervalent iodine reagent was used as oxidant to enable the amination of cyclic and acyclic alkyl ethers with a wide range of amides, imides, and amines. The amination occurred at room temperature and without a transition metal catalyst. The method could be used to synthesize the anti-cancer prodrug Tegafur and its analogues.

Iodine(III)-promoted synthesis of oxazolines from N-allylamides

PhI(OAc)2 (activated by BF3·OEt2) has been used to promote the oxidative cyclization of N-allylamides to give oxazolines. The reaction products are formed in high yield and, when a branched allylic amine is used, high diastereoselectivity. Initial mechanistic experiments suggest that the final C-O bond is formed from a reactive tight ion pair, rather than a neutral external nucleophile.

Substrate-directable heck reactions with arenediazonium salts. The regio- and stereoselective arylation of allylamine derivatives and applications in the synthesis of naftifine and abamines

The palladium-catalyzed, substrate-directable Heck-Matsuda reaction of allylamine derivatives with arenediazonium salts is reported. The reaction proceeds under mild conditions, with excellent regio- and stereochemical control as a function of coordinating groups present in the allylamine substrate. The distance between the olefin moiety and the car-bonylic system seems to play a key role regarding the regiocontrol. The method presents itself as robust, as simple to carry out, and with wide synthetic scope concerning the allylic substrates and the type of arenediazonium employed. The synthetic potential of the method is illustrated by the short total syntheses of the bioactive compounds naftifine, abamine, and abamine SG.

Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine

We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.

COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS

Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.