Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates
The intermolecular alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive anti-Markovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.
Boyington, Allyson J.,Riu, Martin-Louis Y.,Jui, Nathan T.
supporting information
p. 6582 - 6585
(2017/05/29)
Pd-Catalyzed Selective Synthesis of Cyclic Sulfonamides and Sulfinamides Using K2S2O5 as a Sulfur Dioxide Surrogate
A variety of cyclic sulfonamides and sulfinamides could be selectively synthesized under Pd catalysis using haloarenes bearing amino groups and a sulfur dioxide (SO2) surrogate. The amount of base was key in determining the selectivity. Mechanistic studies revealed that sulfinamides were initially formed via an unprecedented formal insertion of sulfur monoxide and were oxidized to sulfonamides in the presence of an iodide ion and DMSO.
Konishi, Hideyuki,Tanaka, Hiromichi,Manabe, Kei
supporting information
p. 1578 - 1581
(2017/04/13)
Preparation of 7a-heteroarylhexahydro-1H-pyrrolizines as cholinergic synaptic transmission modulators.
-
-
(2008/06/13)
More Articles about upstream products of 38749-96-1