38749-96-1Relevant articles and documents
Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates
Boyington, Allyson J.,Riu, Martin-Louis Y.,Jui, Nathan T.
supporting information, p. 6582 - 6585 (2017/05/29)
The intermolecular alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive anti-Markovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.
Preparation of 7a-heteroarylhexahydro-1H-pyrrolizines as cholinergic synaptic transmission modulators.
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, (2008/06/13)
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