38749-96-1

Basic information

• Product Name: Pyridine, 3-iodo-4-methyl- (9CI)
• Synonyms: Pyridine, 3-iodo-4-methyl- (9CI);3-Iodo-4-methylpyridine;3-Iodo-4-picoline;4-Methyl-3-iodopyridine
• CAS NO: 38749-96-1
• Molecular Formula: C₆H₆IN
• Molecular Weight: 219.02301
• Product Categories: PYRIDINE
• Mol File: 38749-96-1.mol

Chemical Properties

• Melting Point: 160 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 240.3 °C at 760 mmHg
• Flash Point: 99.1 °C
• Appearance: /
• Density: 1.81 g/cm³
• Vapor Pressure: 0.0592mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.88±0.18(Predicted)
• CAS DataBase Reference: Pyridine, 3-iodo-4-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-iodo-4-methyl- (9CI)(38749-96-1)
• EPA Substance Registry System: Pyridine, 3-iodo-4-methyl- (9CI)(38749-96-1)

Safety Data

• Hazardous Substances Data: 38749-96-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Pyridine, 3-iodo-4-methyl(9CI) is used as a reactant in the preparation of 7a-heteroarylhexahydro-1H-pyrrolizines. These compounds act as cholinergic synaptic transmission modulators, which are important in the treatment of neurological disorders and cognitive functions. The introduction of the iodine and methyl groups in the pyridine ring provides specific structural features that contribute to the modulation of cholinergic synaptic transmission.

InChI:InChI=1/C6H6IN/c1-5-2-3-8-4-6(5)7/h2-4H,1H3

Upstream product

• 3430-22-6 3-Bromo-4-methylpyridin 
• 3430-27-1 3-amino-4-methylpyridine 
• 540-80-7 tert.-butylnitrite 
• 109-63-7 trifluoroborane diethyl ether 
• 108-89-4 picoline 

Downstream Products

• 1365762-36-2 8-fluoro-2-(4-methylpyridin-3-yl)-5-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one 
• 57842-09-8 3-iodo-isonicotinanilide 
• 57842-10-1 3-iodo-4-pyridinecarboxylic acid 

Relevant articles and documents

Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates

The intermolecular alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive anti-Markovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.

Pd-Catalyzed Selective Synthesis of Cyclic Sulfonamides and Sulfinamides Using K2S2O5 as a Sulfur Dioxide Surrogate

A variety of cyclic sulfonamides and sulfinamides could be selectively synthesized under Pd catalysis using haloarenes bearing amino groups and a sulfur dioxide (SO2) surrogate. The amount of base was key in determining the selectivity. Mechanistic studies revealed that sulfinamides were initially formed via an unprecedented formal insertion of sulfur monoxide and were oxidized to sulfonamides in the presence of an iodide ion and DMSO.