- Continuous synthesis method and reaction device of boron trifluoride complex
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The invention relates to the technical field of boron trifluoride complex preparation, in particular to a continuous synthesis method of a boron trifluoride complex and a reaction device. The invention provides a continuous synthesis method of a boron trifluoride complex, and the method comprises the following steps: in a continuous flow reactor, carrying out complex reaction on an organic matter containing lone pair electrons and boron trifluoride to obtain the boron trifluoride complex, wherein the continuous flow reactor is one or more of a microchannel reactor, a tubular reactor, a stacked mixer and a static mixer. According to the continuous synthesis method provided by the invention, the time of the complexation reaction can be shortened, the reaction efficiency is greatly improved, and the yield of the target product boron trifluoride complex is improved.
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Paragraph 0067-0075
(2021/10/05)
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- Synthesis and reactivity studies of dicationic dihydrogen complexes bearing sulfur-donor ligands: A combined experimental and computational study
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A series of dihydrogen complexes trans-[Ru(η2-H 2){SC(SR)H}(dppe)2][X][BF4] (R = CH 3, X = OTf; R = C6H5CH2, X = BPh4; R = H2C=CHCH2, X = BPh4; dppe = Ph2PCH2CH2PPh2) bearing sulfur-donor ligands has been synthesized by protonation of the (alkyl dithioformate)hydrido complexes trans-[Ru(H){SC(SR)H}(dppe)2][X] by using HBF4·Et2O. Competitive substitution reactions between H2 and SC(SR)H in trans-[Ru(η2-H 2){SC(SR)H}(dppe)2][X][BF4] have been studied by treatment with CH3CN, CO, and P(OCH3)3. These resulted in the expulsion of SC(SR)H from the metal center, thus indicating that the alkyl dithioformate ligand is more labile than H 2. Bonding of alkyl dithioformate ligands (sulfur-donor ligands) trans to H2 have been studied by comparing the H-H distances and chemical-shift values (1H NMR spectroscopy) of the various dihydrogen complexes bearing different trans ligands. This study qualitatively suggests that the alkyl dithioformate ligands in these trans-dihydrogen complexes show a poor π effect, and it is further supported by density functional theory calculations. The first example of a dihydrogen complex bearing dithioformic acid, trans-[Ru(η2-H2){SC(SH)H}(dppe) 2][BF4]2, was obtained by protonation of trans-[Ru(H){SC(S)H}(dppe)2] by using HBF4·Et 2O. Copyright
- Gandhi, Thirumanavelan,Rajkumar, Subramani,Prathyusha,Priyakumar, U. Deva
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p. 1434 - 1443
(2013/05/22)
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- Synthesis and characterisation of some new boron compounds containing the 2,4,6-(CF3)3C6 H2 (fluoromes = Ar), 2,6-(CF3)2C6H3 (fluoroxyl = Ar′), or 2,4-(CF3)2 C6H3 (Ar″) ligands
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Several new boron compounds containing the 2,4,6- (CF3)3C6H2 (fluoromes = Ar), 2,6-(CF3)2C6H3 (fluoroxyl = Ar′) or 2,4-(CF3)2C6H3 (Ar″) ligands have been synthesised from reactions of ArLi, Ar′Li or Ar″Li with BCl3, and characterised by 19F and 11B NMR spectroscopy. Chlorine/fluorine exchanges are evident in these reactions. The crystal and molecular structures of Ar2BF, Ar″3B, Ar2B(OH), Ar′B(OH)2 and Mes2BF (Mes = 2,4,6-Me3C6H2) have been determined by single crystal X-ray diffraction. Ar″3B represents the first example of a compound containing three Ar″ ligands to be structurally characterised. Molecular geometries and GIAO-NMR shifts for several new boron compounds have been calculated at the HF/6-31G* level of theory, and compared with the available experimental results.
- Cornet, Stephanie M.,Dillon, Keith B.,Entwistle, Christopher D.,Fox, Mark A.,Goeta, Andres E.,Goodwin, Helen P.,Marder, Todd B.,Thompson, Amber L.
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p. 4395 - 4405
(2007/10/03)
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- Syntheses, structures, and reactivity studies of half-open ruthenocenes and their oxodienyl analogues
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Improved synthetic routes to Cp*Ru(Pdl) complexes (Pdl = 2,4-dimethylpentadienyl and various oxodienyl ligands) including Cp*Ru(η5-2,4-Me2-C4 H3O) (1), Cp*Ru[η5-2,4-(t-Bu)2-C4 H3O] (1'), and Cp*ru(η5-2,4-Me2-C5 H5) (1″) were developed. When chelating, diphosphines were used as coligands and reactions with O2, Cl2 or H2 led to oxidative addition. A carbon-carbon bond activation was reported.
- Navarro Clemente, M. Elena,Saavedra, Patricia Juárez,Vásquez, Marisol Cervantes,Angeles Paz-Sandoval,Arif, Atta M.,Ernst, Richard D.
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p. 592 - 605
(2008/10/08)
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- Organometallic derivatives of group IIIA and process for their preparation
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New organometallic derivatives of group IIIA are described having general formula M(C6F5)3 wherein M is a metal of group IIIA selected from aluminium, gallium and indium., The above derivatives are prepared by exchange reaction between a metal alkyl MR3 with an organometallic derivative of boron having the formula B(C6F5)3.
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- Boron difluoride compounds useful in photodynamic therapy and production of laser light
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A new group of fluorescent organic compounds having a variety of uses are described. They are especially useful as dye compounds in dye laser systems, and as photochemical agents in the treatment of diseased tissues using photodynamic therapy techniques. The compounds include a tri-cyclic compound having the following structure: STR1 Preferably R1 -R5 =R9 -R12 =C; R7 =B; R6 and R8 =N; R14 =lower n-alkyl or an electron withdrawing group such as CN- ; R16 and R19 are independently selected from the group consisting of lower n-alkyl, a sulfate or an acid or salt thereof, or hydrogen; and R20 =R21 =F. Other compounds include compounds of the formula STR2
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- Process for phenol alkylthiolation and its application to the synthesis of 4-acyl-2-alkylthiophenols
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The invention relates to the preparation of alkylthiophenols by reaction of a dialkyl disulphide with a phenol. In the process according to the invention, the reaction is carried out in the presence of aluminum chloride or of ferric chloride in a solvent of the alkylbenzene type or, soley in the case of methylthiolation, in an excess of dimethyl disulphide. This process makes it possible, in particular to obtain, with a selectivity and in a yield which are excellent, 2-alkylthiophenols which may then be converted into 4-acyl-2-alkylthiophenols by means of a reaction at a temperature ranging from 40° to 100° C. with a complex BF3 :2RCOOH where R denotes an alkyl or propenyl radical, in a proportion of 10 to 15 moles of complex per mole of 2-alkylthiophenol.
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- Ethylene diamine active cardiovascular therapy
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The compound N,N'-dimethyl-N-(3,4,5-trimethoxybenzyl)-N'-[3,3-di-(4-fluorophenyl)-propyl]-ethylenediamine and its salts are described. This compound is useful in the treatment of several cardiovascular pathologies.
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- Compound active in cardiovascular therapy
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The compound N,N?-dimethyl-N-(3,4,5-trimethoxybenzyl)-N?-[3,3-di--(4-fluorophenyl)-propyl]-ethylenediamine and its salts are de-scribed. This compound is useful in the treatment of several cardiovascular pathologies.
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- Herbicidal N-haloacetyl-2-methyl-6-substituted methoxymethylanilines
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Compounds of the formula STR1 wherein R1 is alkyl or alkoxy; R2 is alkenyl having 2 to 10 carbon atoms, substituted alkyl of 1 to 10 carbon atoms or substituted alkenyl of 1 to 10 carbon atoms substituted with 1 or 2 hydroxy groups or 1 or 2 alkoxy groups of 1 to 4 carbon atoms or 1 or 2 alkenyloxy groups of 2 to 4 carbon atoms; acyl, and ketal group of the formula STR2 wherein n=2, 3 or 4, R4 is alkyl and R5 is hydrogen or alkyl, an oxime of the formula STR3 wherein R6 is hydrogen or alkyl; R3 is hydrogen or alkyl; X is halo have herbicidal activity.
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- Benzazocine derivatives and process for preparing the same
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Benzazocine derivatives represented by the formula STR1 which have an excellent analgesic action and are useful for use in drugs, and a process for preparing the same are disclosed.
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- Cyclohexane diol composition
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Described is a mixture of cyclohexane diol intermediates produced while carrying out a process wherein a mixture of compounds having a sandalwood aroma is prepared, which process comprises; 1. Reacting catechol with camphene in the presence of a Friedel Crafts Catalyst to form a first alkylation product; and then 2. Treating said first alkylation product with hydrogen in the presence of a hydrogenation catalyst, thus forming, initially, the diol intermediates of our invention and then, on continuing the hydrogenation, the mixture useful in perfumery.
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- Process for preparing aldehydes from olefins
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Aldehydes are prepared by reacting an olefin with hydrogen peroxide in the presence of at least one boron compound and at least one compound of one of the metals of the fifth and/or sixth Secondary Group of the Periodic Table.
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- Process for preparing aldehydes from oxirane compounds
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Aldehydes are prepared by reacting an oxirane compound with hydrogen peroxide in the presence of a boron compound.
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