- Preparation method of N,N'-methylene bis (N'-3-hydroxymethyl-2, 5-dioxo-4-imidazolyl) urea
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The invention discloses a preparation method of N,N'-methylene bis(N'-3-hydroxymethyl-2, 5-dioxo-4-imidazolyl) urea. The method comprises the following steps: weighing allantoin and formaldehyde according to a molar ratio of 1: (1 to 1.2), adding sodium hydroxide as a catalyst, carrying out stirring reflux for 4-8h at the temperature of 70-74 DEG C, using an acetic acid solution to adjust the pH to be neutral, and carrying out reduced pressure distillation to enable water to be steamed out; after reduced pressure dehydration is carried out on the material, adding the material into ethanol while stirring, separating out crystal, filtering, and washing with deionized water; sequentially putting the washed solid into heat pump drying ovens for dehumidification drying and vacuum drying to obtain the product. The preparation method combines heat pump drying and vacuum drying, and the heat pump drying has functions of drying and dehumidifying, so that the energy consumption is less, the time of the vacuum drying is shortened, the drying temperature is low, and the drying time is short; the preparation method has the advantages of improving the quality of the product, reducing energy consumption and lowering production cost.
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Paragraph 0016-0030
(2017/02/24)
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- Antimicrobial wipes which provide improved residual benefit versus gram positive bacteria
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The present invention relates to an antimicrobial wipe comprising a porous or absorbent sheet impregnated with an antimicrobial cleansing composition, wherein the antimicrobial cleansing composition comprises from about 0.001% to about 5.0%, by weight of the antimicrobial cleansing composition, of an antimicrobial active; from about 0.05% to about 10%, by weight of the antimicrobial cleansing composition, of an anionic surfactant; from about 0.1% to about 10%, by weight of the antimicrobial cleansing composition, of a proton donating agent; and from about 3% to about 99.85%, by weight of the antimicrobial cleansing composition, water; wherein the composition is adjusted to a pH of from about 3.0 to about 6.0; wherein the antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 0.5; and wherein the antimicrobial cleansing composition has a Mildness Index of less than about 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.
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- Mild, rinse-off antimicrobial liquid cleansing compositions containing salicyclic acid
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The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5.0%, by weight of the cleansing composition, of an antimicrobial active; from about 6% to about 16%, by weight of the cleansing composition, of an anionic surfactant, wherein at least about 67% of the anionic surfactant is selected from the group consisting of Class A surfactants, Class C surfactants, and mixtures thereof, wherein the ratio of Class A surfactant to Class C is from about 100:0 to about 1.5:1; from about 2% to about 4%, by weight of the cleansing composition, of a proton donating agent having a Biological Activity Index, Z, of greater than about 0.75, wherein the proton donating agent is such that the composition is essentially free of C4-C20 alkyl fatty acid, and wherein from about 0.15% to about 2%, by weight of the cleansing composition, of the proton donating agent is salicylic acid; a mildness enhancing agent selected from the group consisting of from about 20% to about 70%, by weight of the anionic surfactant, of a mildness enhancing cosurfactant; from about 0.1% to about 1.0%, by weight of the cleansing composition, of a mildness enhancing polymer; and mixtures thereof, and from about 35% to about 95.75%, by weight of the cleansing composition, of water; wherein the composition is adjusted to a pH of greater than about 3 and less than about 6. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.
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- Mild, rinse-off antimicrobial liquid cleansing compositions which provide residual benefit versus gram negative bacteria
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The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent; and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Negative Residual Effectiveness Index of greater than about 0.3, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.
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