393-15-7

Basic information

• Product Name: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE
• Synonyms: 3-AMINO-6-METHOXYBENZOTRIFLUORIDE;3-TRIFLUOROMETHYL-P-ANISIDINE;5-AMINO-2-METHOXYBENZOTRIFLUORIDE;4-METHOXY-3-(TRIFLUOROMETHYL)ANILINE;TIMTEC-BB SBB002596;5-amino-2-methoxybenzotrifluoride,97%;3-Amino-6-methoxybenzotriflyoride;3-Amino-6-methoxybenzotrifloride
• CAS NO: 393-15-7
• Molecular Formula: C₈H₈F₃NO
• Molecular Weight: 191.15
• EINECS: -0
• Mol File: 393-15-7.mol

Chemical Properties

• Melting Point: 28 °C
• Boiling Point: 112 °C
• Flash Point: 112°C/18mm
• Appearance: Solid
• Density: 1.28 g/cm³
• Vapor Pressure: 0.0226mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.98±0.10(Predicted)
• BRN: 2723972
• CAS DataBase Reference: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE(393-15-7)
• EPA Substance Registry System: 5-AMINO-2-METHOXYBENZOTRIFLUORIDE(393-15-7)

Safety Data

• Hazard Codes: Xi,T,Xn
• Statements: 20/21/22-36/37/38-52-22
• Safety Statements: 26-36/37/39
• HazardClass: TOXIC
• Hazardous Substances Data: 393-15-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-AMINO-2-METHOXYBENZOTRIFLUORIDE is used as an intermediate in the production of active pharmaceutical ingredients. Its stability and reactivity make it suitable for the synthesis of various medicinal compounds, contributing to the development of new drugs and therapies.
Used in Agrochemical Industry:
In the agrochemical sector, 5-AMINO-2-METHOXYBENZOTRIFLUORIDE is utilized as a building block for the synthesis of crop protection products. Its properties allow for the creation of effective and stable agrochemicals that protect crops from pests and diseases.
Used in Dye and Pigment Production:
5-AMINO-2-METHOXYBENZOTRIFLUORIDE is used as an intermediate in the production of various dyes and pigments. Its chemical structure enables the creation of a wide range of colorants used in different applications, such as textiles, plastics, and inks.
Used in Materials Science:
In the field of materials science, 5-AMINO-2-METHOXYBENZOTRIFLUORIDE is employed in the manufacture of organic compounds. Its versatility and stability contribute to the development of innovative materials with unique properties for various applications, including electronics, coatings, and advanced materials.
Overall, 5-AMINO-2-METHOXYBENZOTRIFLUORIDE is a multifaceted chemical compound with a broad spectrum of applications across different industries, making it an indispensable component in the development of new products and technologies.

InChI:InChI=1/C8H8F3NO/c1-13-7-3-2-5(12)4-6(7)8(9,10)11/h2-4H,12H2,1H3

Upstream product

• 1514-11-0 4-bromo-1-methoxy-2-(trifluoromethyl)benzene 
• 654-76-2 1-methoxy-4-nitro-2-(trifluoromethyl)benzene 
• 7439-89-6 iron 
• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 777-37-7 4-chloro-3-(trifluoromethyl)nitrobenzene 

Downstream Products

• 1141713-96-3 C₁₀H₇F₆NO₂ 
• 70338-59-9 1-Methyl-cyclopropanecarboxylic acid (4-methoxy-3-trifluoromethyl-phenyl)-amide 
• 789454-93-9 C₈H₇BrF₃NO 
• 478837-04-6 N-[4-methoxy-2-methyl-3-(trifluoromethyl)-phenyl]-2,2-dimethylpropanamide 

Relevant articles and documents

Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds

Arylmetals are highly valuable carbon nucleophiles that are readily and inexpensively prepared from aryl halides or arenes and widely used on both laboratory and industrial scales to react directly with a wide range of electrophiles. Although C-C bond formation has been a staple of organic synthesis, the direct transfer of primary amino (-NH2) and hydroxyl (-OH) groups to arylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge because of the absence of suitable heteroatom-transfer reagents. Here, we demonstrate the use of bench-stable N-H and N-alkyl oxaziridines derived from readily available terpenoid scaffolds as efficient multifunctional reagents for the direct primary amination and hydroxylation of structurally diverse aryl- and heteroarylmetals. This practical and scalable method provides one-step synthetic access to primary anilines and phenols at low temperature and avoids the use of transition-metal catalysts, ligands and additives, nitrogen-protecting groups, excess reagents and harsh workup conditions.

Mild and highly selective palladium-catalyzed monoarylation of ammonia enabled by the use of bulky biarylphosphine ligands and palladacycle precatalysts

A method for the Pd-catalyzed arylation of ammonia with a wide range of aryl and heteroaryl halides, including challenging five-membered heterocyclic substrates, is described. Excellent selectivity for monoarylation of ammonia to primary arylamines was achieved under mild conditions or at rt by the use of bulky biarylphosphine ligands (L6, L7, and L4) as well as their corresponding aminobiphenyl palladacycle precatalysts (3a, 3b, and 3c). As this process requires neither the use of a glovebox nor high pressures of ammonia, it should be widely applicable.

Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases

Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Palladium-catalyzed silane/siloxane reductions in the one-pot conversion of nitro compounds into their amines, hydroxylamines, amides, sulfonamides, and carbamates

A combination of palladium(II) acetate, aqueous potassium fluoride, and polymethylhydrosiloxane (PMHS) facilitates the room-temperature reduction of aromatic nitro compounds to anilines. These reactions tend to be quick (30 min), high-yielding, and tolerate a range of other functional groups. Replacement of PMHS/KF with triethylsilane allows for the reduction of aliphatic nitro compounds to their corresponding hydroxylamines. Depending on the substrate, both conditions can allow for the in situ conversion of the product amines into amides, sulfonamides, and carbamates. Georg Thieme Verlag Stuttgart.

Diaminopyrimidines as P2X3 and P2X2/3 antagonists

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

ALPHA-(TRIFLUOROMETHYL-SUBSTITUTED ARYLOXY, ARYLAMINO, ARYLTHIO OR ARYLMETHYL)-TRIFLUOROMETHYL-SUBSTITUTED PHENYLACETIC ACIDS AND DERIVATIVES AS ANTIDIABETIC AGENTS

Compounds having a formula (1) or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.

DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES

The invention relates to the use of diaryl urea derivatives in the treatment of protein kinase dependent diseases or for the manufacture of pharmaceutical compositions for use in the treatment of said diseases, methods of use of diaryl urea derivatives in the treatment of said diseases, pharmaceutical preparations comprising diaryl urea derivatives for the treatment of said diseases, diaryl urea derivatives for use in the treatment of said diseases, novel diaryl urea derivatives, pharmaceutical preparations comprising these novel diaryl urea derivatives, processes for the manufacture of the novel diaryl urea derivatives, the use or methods of use of the novel diaryl urea derivatives as mentioned above, and/or these novel diaryl urea derivatives for use in the treatment of the animal or human body.

Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses

Compounds of the formula: are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.