401588-96-3

Basic information

• Product Name: Benzamide, 2-amino-N-1H-benzimidazol-2-yl- (9CI)
• Synonyms: Benzamide, 2-amino-N-1H-benzimidazol-2-yl- (9CI)
• CAS NO: 401588-96-3
• Molecular Formula: C₁₄H₁₂N₄O
• Molecular Weight: 252.27128
• Product Categories: AMIDE
• Mol File: 401588-96-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzamide, 2-amino-N-1H-benzimidazol-2-yl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-amino-N-1H-benzimidazol-2-yl- (9CI)(401588-96-3)
• EPA Substance Registry System: Benzamide, 2-amino-N-1H-benzimidazol-2-yl- (9CI)(401588-96-3)

Safety Data

• Hazardous Substances Data: 401588-96-3(Hazardous Substances Data)

Upstream product

• 934-32-7 1H-benzimidazol-2-amine 
• 118-48-9 isatoic anhydride 

Downstream Products

• 1427330-74-2 3-(1H-benzo[d]imidazol-2-yl)-2-(4-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one 
• 872460-49-6 benzo[4,5]imidazo[1,2-a]thieno[2,3-e]pyrimidine 
• 1613287-68-5 2-fluorobenzo[4,5]imidazo[1,2-a]quinazoline 
• 1613287-78-7 3-(1H-benzo[d]-imidazol-2-yl)-2-(2-bromophenyl)-2,3-dihydroquinazolin-4(1H)-one 

Relevant articles and documents

A facile synthesis of new 3-(2-benzimidazolyl)-2-alkyl-4-(3H)-quinazolinones under microwave irradiation

Preparation of 2-amino-N-(1-H-benzimidazol-2-yl)benzamide and a variety of new 3-(2-benzimidazolyl)-2-alkyl-4-(3H)-quinazolinones using isatoic anhydride, 2-aminobenzimidazole and orthoesters under microwave irradiation are described.

Identification of potent orally active factor Xa inhibitors based on conjugation strategy and application of predictable fragment recommender system

Anticoagulant agents have emerged as a promising class of therapeutic drugs for the treatment and prevention of arterial and venous thrombosis. We investigated a series of novel orally active factor Xa inhibitors designed using our previously reported conjugation strategy to boost oral anticoagulant effect. Structural optimization of anthranilamide derivative 3 as a lead compound with installation of phenolic hydroxyl group and extensive exploration of the P1 binding element led to the identification of 5-chloro-N-(5-chloro-2-pyridyl)-3-hydroxy-2-{[4-(4-methyl-1,4-diazepan-1-yl)benzoyl]amino}benzamide (33, AS1468240) as a potent factor Xa inhibitor with significant oral anticoagulant activity. We also reported a newly developed Free-Wilson-like fragment recommender system based on the integration of R-group decomposition with collaborative filtering for the structural optimization process.