2-amino-N-(1H-benzimidazol-2-yl)benzamide

Base Information

• Chemical Name: 2-amino-N-(1H-benzimidazol-2-yl)benzamide
• CAS No.: 401588-96-3
• Molecular Formula: C14H12 N4 O
• Molecular Weight: 252.275
• DSSTox Substance ID: DTXSID30398740
• Nikkaji Number: J1.920.507J
• Wikidata: Q82200881
• Mol file: 401588-96-3.mol

Synonyms:2-amino-N-(1H-benzimidazol-2-yl)benzamide;401588-96-3;DTXSID30398740;AKOS006037366;N-(1H-Benzimidazole-2-yl)-2-aminobenzamide

Chemical Property of 2-amino-N-(1H-benzimidazol-2-yl)benzamide

Chemical Property:

• PSA: 87.29000
• LogP: 3.36260
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 252.10111102
• Heavy Atom Count: 19
• Complexity: 335

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NC2=NC3=CC=CC=C3N2)N

Technology Process of 2-amino-N-(1H-benzimidazol-2-yl)benzamide

There total 1 articles about 2-amino-N-(1H-benzimidazol-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1H-benzimidazol-2-amine (934-32-7) + isatoic anhydride (118-48-9) → 2-amino-N-(1H-benzo[d]imidazol-2-yl)benzamide (401588-96-3)

Guidance literature:

With toluene-4-sulfonic acid; In N,N-dimethyl acetamide; microwave irradiation;

DOI:10.1016/S0040-4020(03)00696-3

Reference yield: 98.0%

benzaldehyde (100-52-7) + 2-amino-N-(1H-benzo[d]imidazol-2-yl)benzamide (401588-96-3) → 3-(1H-benzo[d]imidazol-2-yl)-2-phenyl-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:

In N,N-dimethyl-formamide; at 130 ℃; for 0.166667h; Microwave irradiation; Sealed tube;

DOI:10.1080/00397911.2016.1277761

Reference yield: 93.0%

4-methoxy-benzaldehyde (123-11-5) + 2-amino-N-(1H-benzo[d]imidazol-2-yl)benzamide (401588-96-3) → 3-(1H-benzo[d]imidazol-2-yl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Guidance literature:

In N,N-dimethyl-formamide; at 130 ℃; for 0.166667h; Microwave irradiation; Sealed tube;

DOI:10.1080/00397911.2016.1277761

upstream raw materials:

1H-benzimidazol-2-amine

isatoic anhydride

Downstream raw materials:

3-(1H-benzo[d]-imidazol-2-yl)-2-(2-bromophenyl)-2,3-dihydroquinazolin-4(1H)-one

2-fluorobenzo[4,5]imidazo[1,2-a]quinazoline

benzo[4,5]imidazo[1,2-a]thieno[2,3-e]pyrimidine

3-(1H-benzo[d]imidazol-2-yl)-2-(4-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one