- HETEROCYCLIC LIPXON ANALOGS AND USES THEROF
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The present invention relates to a compound of formula (I): wherein L is an optionally substituted heterocyclic group excluding unsubstituted monocyclic pyridine groups; wherein a is 0, 1 or 2; wherein R1 is H or with R2 is a bond; wherein R2 is an optionally substituted alkoxy or aryloxy group, or with R1 forms a bond; wherein R3 is an optionally substituted alkyl group; and wherein R4 is CH2, CMe2 or O. Such compounds may be used in the treatment or prophylaxis of a disease or condition in which inhibition of acute inflammation and/or promotion of its resolution and/or suppression of fibrosis.
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Page/Page column 107; 108
(2018/03/09)
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- Phenyl sulphonyl acetaldehyde diethyl acetal: A new robust 1,2-diol protective group
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A simple preparation of a novel resilient protective group for 1,2-diols is described herein which is remarkably stable in the presence of extremely harsh basic conditions as well as acidic media. The title reagent's versatility is detailed with numerous examples.
- Chandrasekhar,Srinivas, Ch.,Srihari
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p. 895 - 902
(2007/10/03)
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- Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11, 13-hexadecatetraenoate, an analogue of 15R-lipoxin A4
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We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11, 13-hexadecatetraenoate, a compound that has been described as a metabolically stable analogue of 15R-lipoxin A4.
- Phillips, Eifion D.,Chang, Hui-Fang,Holmquist, Christopher R.,McCauley, John P.
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p. 3223 - 3226
(2007/10/03)
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- Bromoacetone: A new protective group for 1,2-diols cleavable with zinc
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Bromoacetone has been utilized for the first time as an excellent protective group for 1,2-diols that can be cleaved under neutral conditions viz., refluxing in Zn-MeOH.
- Chandrasekhar,Srinivas,Suresh Kumar,Muralidhar
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p. 1147 - 1152
(2007/10/03)
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- New non-proteogenic aminoacids bearing an enol aryl-ether moiety
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Aminoacids bearing an enol aryl-ether moiety have been synthesized by a new method allowing a great versatility in the introduction of N-protective groups and enol ether functions. This method involves a Wittig-Horner condensation affording alpha, beta-dehydrohomoserine ether derivatives, followed by a regio and stereoselective isomerization into the desired E enol ether. Clean deprotection was achieved providing new 2-amino-4-aryloxybut-3(E)-enoic acids 3.
- Daumas,Vo-Quang,Le Goffic
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p. 2373 - 2384
(2007/10/02)
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- A New and Efficient Heterogeneous System for the Oxidative Cleavage of 1,2-Diols and the Oxidation of Hydroquinones
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Sodium periodate/wet silica gel in the presence of dichloromethane is an efficient reagent for the oxidative cleavage of 1,2-diols and the oxidation of hydroquinones.This easily prepared reagent provides a good alternative of classical metaperiodate oxidation, especially for the preparation of aldehydes, which easily form hydrates.
- Daumas, M.,Vo-Quang, Y.,Vo-Quang, L.,Goffic, F. Le
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