405-90-3

Usage

Derivative of 1,2-propanediol

It is a modified version of 1,2-propanediol (propylene glycol) a common chemical compound used in various applications.

Fluorophenoxy group

Contains a 4-fluorophenoxy group, which is a structural component that consists of a phenyl ring (a six-carbon ring) with a fluorine atom attached to it and an ether linkage (-O-) to the propanediol backbone.

Use as an intermediate

Often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals meaning it is a reactant in the production of other chemicals, which are then used in the final products.

Industrial applications

May be used as a solvent or a chemical intermediate in various industrial applications, such as the production of polymers, paints, and coatings.

Upstream product

• 371-41-5 4-Fluorophenol 
• 96-24-2 3-monochloro-1,2-propanediol 
• 565455-84-7 2-benzenesulfonylmethyl-4-(4-fluoro-phenoxymethyl)-[1,3]dioxolane 

Downstream Products

• 620973-14-0 4-{(4S,5R)-5-[(1E,3E,7E)-(S)-10-(4-Fluoro-phenoxy)-9-hydroxy-deca-1,3,7-trien-5-ynyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-butyric acid methyl ester 
• 620973-06-0 (7E,9E,13E)-(5S,6R,15S)-16-(4-Fluoro-phenoxy)-5,6,15-trihydroxy-hexadeca-7,9,13-trien-11-ynoic acid methyl ester 
• 620973-10-6 1-(4-fluoro-phenoxy)-4-trimethylsilanyl-but-3-yn-2-ol 
• 524714-06-5 (1E,3S)-1-bromo-4-(4-fluorophenoxy)-3-hydroxy-1-butene 
• 67693-57-6 4-(p-fluorophenoxy)-3-hydroxy-1-butyne 
• 59769-38-9 2-(4-fluorophenoxy)acetaldehyde 
• 141540-73-0 Methyl 4-(4-fluorophenoxy)-2-N-formylaminobut-2(Z)-enoate 
• 141540-64-9 Methyl 4-(4-fluorophenoxy)-2-N-formylaminobut-2(E)-enoate 

Relevant academic research and scientific papers

HETEROCYCLIC LIPXON ANALOGS AND USES THEROF

The present invention relates to a compound of formula (I): wherein L is an optionally substituted heterocyclic group excluding unsubstituted monocyclic pyridine groups; wherein a is 0, 1 or 2; wherein R1 is H or with R2 is a bond; wherein R2 is an optionally substituted alkoxy or aryloxy group, or with R1 forms a bond; wherein R3 is an optionally substituted alkyl group; and wherein R4 is CH2, CMe2 or O. Such compounds may be used in the treatment or prophylaxis of a disease or condition in which inhibition of acute inflammation and/or promotion of its resolution and/or suppression of fibrosis.

Phenyl sulphonyl acetaldehyde diethyl acetal: A new robust 1,2-diol protective group

A simple preparation of a novel resilient protective group for 1,2-diols is described herein which is remarkably stable in the presence of extremely harsh basic conditions as well as acidic media. The title reagent's versatility is detailed with numerous examples.

Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11, 13-hexadecatetraenoate, an analogue of 15R-lipoxin A4

We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11, 13-hexadecatetraenoate, a compound that has been described as a metabolically stable analogue of 15R-lipoxin A4.

Bromoacetone: A new protective group for 1,2-diols cleavable with zinc

Bromoacetone has been utilized for the first time as an excellent protective group for 1,2-diols that can be cleaved under neutral conditions viz., refluxing in Zn-MeOH.

New non-proteogenic aminoacids bearing an enol aryl-ether moiety

Aminoacids bearing an enol aryl-ether moiety have been synthesized by a new method allowing a great versatility in the introduction of N-protective groups and enol ether functions. This method involves a Wittig-Horner condensation affording alpha, beta-dehydrohomoserine ether derivatives, followed by a regio and stereoselective isomerization into the desired E enol ether. Clean deprotection was achieved providing new 2-amino-4-aryloxybut-3(E)-enoic acids 3.

A New and Efficient Heterogeneous System for the Oxidative Cleavage of 1,2-Diols and the Oxidation of Hydroquinones

Sodium periodate/wet silica gel in the presence of dichloromethane is an efficient reagent for the oxidative cleavage of 1,2-diols and the oxidation of hydroquinones.This easily prepared reagent provides a good alternative of classical metaperiodate oxidation, especially for the preparation of aldehydes, which easily form hydrates.