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CAS

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405274-90-0

1-(2,4-difluorobenzyl)-3-formyl-1H-indole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 405274-90-0 Structure

  • Basic information

    1. Product Name: 1-(2,4-difluorobenzyl)-3-formyl-1H-indole
    2. Synonyms: 1-(2,4-difluorobenzyl)-3-formyl-1H-indole
    3. CAS NO:405274-90-0
    4. Molecular Formula: C16H11F2NO
    5. Molecular Weight: 271
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 405274-90-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(2,4-difluorobenzyl)-3-formyl-1H-indole(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(2,4-difluorobenzyl)-3-formyl-1H-indole(405274-90-0)
    11. EPA Substance Registry System: 1-(2,4-difluorobenzyl)-3-formyl-1H-indole(405274-90-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 405274-90-0(Hazardous Substances Data)

405274-90-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 405274-90-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,5,2,7 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 405274-90:
(8*4)+(7*0)+(6*5)+(5*2)+(4*7)+(3*4)+(2*9)+(1*0)=130
130 % 10 = 0
So 405274-90-0 is a valid CAS Registry Number.

405274-90-0Relevant articles and documents

Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition

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Page/Page column 14, (2010/02/06)

The present invention relates to novel indole derivatives, their method of preparation and their pharmacological activity as antimycotic and/or antiparasitic compounds.

Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives

Na, Young-Min,Le Borgne, Marc,Pagniez, Fabrice,Le Baut, Guillaume,Le Pape, Patrice

, p. 75 - 87 (2007/10/03)

A series of 1-benzyl-3-(imidazol-1-ylmethyl)indole derivatives 35-46 were prepared under mild reaction conditions and tested for their antifungal activity. Pharmacomodulation at N1, C2 and C5 of the indole ring and at the level of the alkyl chain (R1) was carried out starting from the corresponding 3-acylindoles 6, 7 or 3-formylindoles 11-22. Target imidazolyl compounds 35-46 were obtained in satisfactory yields by CO2 elimination from the intermediate carbamates. All of the compounds were evaluated in vitro against two human fungal pathogens, Candida albicans (CA980001) and Aspergillus fumigatus (AF980003); amphotericin B, fluconazole and itraconazole were used as references. Seven out of 27 compounds (35b, 35e, 35g, 35h, 36a, 38a and especially 40a) exerted significant antifungal activity against C. albicans, with MIC in the range of 1-6 μg mL-1. As regards inhibitory activity against A. fumigatus, the MIC figures of most of our compounds were in excess of 20 μg mL-1 in contrast to the reference drugs, amphotericin B and itraconazole, whose MIC90 and MIC80 values were 0.14 and 0.50 μg mL-1, respectively. The most potent compound, 45a, exhibited MIC value (8±1 μg mL-1) 16-fold higher than that of itraconazole.

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