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Methanone, (4-fluorophenyl)-1H-indol-7-yl-, also known as 7-(4-Fluorophenyl)-1H-indole-2,3-dione, is a chemical compound belonging to the indole class of organic compounds. It is characterized by a fluoro-substituted phenyl ring attached to the 1H-indol-7-yl moiety through a methanone group. With the molecular formula C17H13FNO, Methanone, (4-fluorophenyl)-1H-indol-7-yl- has been the subject of research for its potential therapeutic applications in medicinal chemistry and pharmaceutical research. It demonstrates intriguing pharmacological properties and holds promise as a lead compound for the development of new drugs targeting a variety of biological processes. Further investigation is required to fully elucidate its biological activity and potential applications in medicine and other fields.

405275-40-3

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405275-40-3 Usage

Uses

Used in Pharmaceutical Research:
Methanone, (4-fluorophenyl)-1H-indol-7-ylis utilized as a lead compound in pharmaceutical research for its potential therapeutic applications. Its unique structure and pharmacological properties make it a valuable candidate for the development of new drugs targeting various biological processes.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Methanone, (4-fluorophenyl)-1H-indol-7-ylserves as a key compound for the design and synthesis of novel therapeutic agents. Its chemical properties and interactions with biological targets can provide insights into the development of more effective and targeted treatments for various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 405275-40-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,5,2,7 and 5 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 405275-40:
(8*4)+(7*0)+(6*5)+(5*2)+(4*7)+(3*5)+(2*4)+(1*0)=123
123 % 10 = 3
So 405275-40-3 is a valid CAS Registry Number.

405275-40-3Relevant articles and documents

Anticancer active indole derivatives, synthetic method and use thereof

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Paragraph 0065; 0066; 0067; 0068; 0069; 0070, (2017/08/25)

The present invention relates to an indole derivative and uses of the indole derivative in preparation of anti-cancer drugs for tumor inhibition, wherein a cyano indole compound and a boric acid compound can be subjected to one-step synthesis in the prese

Palladium-catalyzed direct addition of arylboronic acids to 2-aminobenzonitrile derivatives: Synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines, and 7-benzoylindoles

Chen, Jiuxi,Ye, Leping,Su, Weike

supporting information, p. 8204 - 8211 (2015/01/08)

A palladium-catalyzed direct addition of arylboronic acids to unprotected 2-aminobenzonitriles has been developed, leading to a wide range of 2-aminobenzophenones with moderate to excellent yields. The transformation has broad scope and high functional group tolerance. Moreover, 2-oxoindoline-7-carbonitrile and indole-7-carbonitrile were applicable to this process for the construction of 7-benzoyl-2-oxoindolines and 7-benzoylindoles, respectively. Among the compounds examined, compound 4e possessed the most potent anticancer activity against H446 and HGC-27 in vitro, with IC50 values of 0.02 μmol L-1 and 0.09 μmol L-1, respectively, while compound 4a showed the best potent anticancer activity against SGC-7901 with an IC50 value of 0.01 μmol L-1. Furthermore, we also performed in silico molecular docking calculations to investigate the interaction mode and binding affinity between the examined compounds and their tubulin target. This journal is

Rhodium enalcarbenoids: Direct synthesis of indoles by rhodium(II)- catalyzed [4+2] benzannulation of pyrroles

Dawande, Sudam Ganpat,Kanchupalli, Vinaykumar,Kalepu, Jagadeesh,Chennamsetti, Haribabu,Lad, Bapurao Sudam,Katukojvala, Sreenivas

supporting information, p. 4076 - 4080 (2014/05/06)

Disclosed herein is the design of an unprecedented electrophilic rhodium enalcarbenoid which results from rhodium(II)-catalyzed decomposition of a new class of enaldiazo compounds. The synthetic utility of these enalcarbenoids has been successfully demonstrated in the first transition-metal-catalyzed [4+2] benzannulation of pyrroles, thus leading to substituted indoles. The new benzannulation has been applied to the efficient synthesis of the natural product leiocarpone as well as a potent adipocyte fatty-acid binding protein inhibitor. Fat cat: A new class of enaldiazo compounds resulted in the first transition-metal-catalyzed [4+2] benzannulation of pyrroles to deliver indoles. The benzannulation is proposed to involve an unprecedented diacceptor rhodium enalcarbenoid. The reaction was used in the highly efficient synthesis of the natural product leiocarpone and a potent adipocyte fatty-acid binding protein inhibitor.

Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition

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Page/Page column 20, (2010/02/06)

The present invention relates to novel indole derivatives, their method of preparation and their pharmacological activity as antimycotic and/or antiparasitic compounds.

Preparation and pharmacological profile of 7-(α-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors

Marchand, Pascal,Le Borgne, Marc,Palzer, Martina,Le Baut, Guillaume,Hartmann, Rolf W.

, p. 1553 - 1555 (2007/10/03)

Aromatase (P450 arom) is a target of pharmacological interest for the treatment of breast cancer. New series of 7-(α-azolylbenzyl)-1H-indoles and indolines were synthesized as non-steroidal inhibitors of P450 arom. Selectivity was studied towards P450 17α enzyme. The most active compound, 1-ethyl-7-[(imidazol-1-yl)(4-chlorophenyl)methyl]-1H-indole 12c exhibited promising relative potency (rp) of 336 (rp of aminoglutethimide=1) and most of the described azoles were active and selective towards P450 arom.

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