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4-(4,4-DIMETHYL-PIPERIDIN-1-YL)-BENZOIC ACID is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 406233-26-9 Structure
  • Basic information

    1. Product Name: 4-(4,4-DIMETHYL-PIPERIDIN-1-YL)-BENZOIC ACID
    2. Synonyms: 4-(4,4-DIMETHYL-PIPERIDIN-1-YL)-BENZOIC ACID;4-(4,4-dimethyl-1-piperidinyl)Benzoic acid;4-(4,4-Dimethylpiperidin-1-yl)
    3. CAS NO:406233-26-9
    4. Molecular Formula: C14H19NO2
    5. Molecular Weight: 233.30616
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 406233-26-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 388.003 °C at 760 mmHg
    3. Flash Point: 188.457 °C
    4. Appearance: /
    5. Density: 1.097 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.546
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-(4,4-DIMETHYL-PIPERIDIN-1-YL)-BENZOIC ACID(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-(4,4-DIMETHYL-PIPERIDIN-1-YL)-BENZOIC ACID(406233-26-9)
    12. EPA Substance Registry System: 4-(4,4-DIMETHYL-PIPERIDIN-1-YL)-BENZOIC ACID(406233-26-9)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36
    3. Safety Statements: 26
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 406233-26-9(Hazardous Substances Data)

406233-26-9 Usage

Uses

4-(4,4-Dimethylpiperidin-1-yl)benzoic acid

Check Digit Verification of cas no

The CAS Registry Mumber 406233-26-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,6,2,3 and 3 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 406233-26:
(8*4)+(7*0)+(6*6)+(5*2)+(4*3)+(3*3)+(2*2)+(1*6)=109
109 % 10 = 9
So 406233-26-9 is a valid CAS Registry Number.
InChI:InChI=1/C14H19NO2/c1-14(2)7-9-15(10-8-14)12-5-3-11(4-6-12)13(16)17/h3-6H,7-10H2,1-2H3,(H,16,17)

406233-26-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(4,4-Dimethylpiperidin-1-yl)benzoic acid

1.2 Other means of identification

Product number -
Other names 4-(4,4-Dimethylpiperidin-1-Yl)Benzoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:406233-26-9 SDS

406233-26-9Relevant articles and documents

Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPARγ agonists

Tanaka, Yuta,Gamo, Kanae,Oyama, Takuji,Ohashi, Masao,Waki, Minoru,Matsuno, Kenji,Matsuura, Nobuyasu,Tokiwa, Hiroaki,Miyachi, Hiroyuki

, p. 4001 - 4005 (2014/09/17)

We previously reported that a α-benzylphenylpropanoic acid-type hPPARγ-selective agonist with a piperidine ring as the hydrophobic tail part (3) exhibited sub-micromolar-order hPPARγ agonistic activity. In order to enhance the activity, we planned to carr

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

Wendt, Michael D.,Shen, Wang,Kunzer, Aaron,McClellan, William J.,Bruncko, Milan,Oost, Thorsten K.,Ding, Hong,Joseph, Mary K.,Zhang, Haichao,Nimmer, Paul M.,Ng, Shi-Chung,Shoemaker, Alexander R.,Petros, Andrew M.,Oleksijew, Anatol,Marsh, Kennan,Bauch, Joy,Oltersdorf, Tilman,Belli, Barbara A.,Martineau, Darlene,Fesik, Stephen W.,Rosenberg, Saul H.,Elmore, Steven W.

, p. 1165 - 1181 (2007/10/03)

Development of a rationally designed potentiator of cancer chemotherapy, via inhibition of Bcl-XL function, is described. Lead compounds generated by NMR screening and directed parallel synthesis displayed sub-μM binding but were strongly deactivated in the presence of serum. The dominant component of serum deactivation was identified as domain III of human serum albumin (HSA); NMR solution structures of inhibitors bound to both Bcl-X L and HSA domain III indicated two potential optimization sites for separation of affinities. Modifications at both sites resulted in compounds with improved Bcl-XL binding and greatly increased activity in the presence of human serum, culminating in 73R, which bound to Bcl-XL with a Ki of 0.8 μM. In a cellular assay 73R reversed the protection afforded by Bcl-XL overexpression against cytokine deprivation in FL5.12 cells with an EC50 of 0.47 μM. 73R showed little effect on the viability of the human non small cell lung cancer cell line A549. However, consistent with the proposed mechanism, 73R potentiated the activity of paclitaxel and UV irradiation in vitro and potentiated the antitumor efficacy of paclitaxel in a mouse xenograft model.

N-sulfonylcarboximidamide apoptosis promoters

-

Page/Page column 12, (2008/06/13)

Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

N-acylsulfonamide apoptosis promoters

-

, (2008/06/13)

N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.

N-Acylsulfonamide apoptosis promoters

-

, (2008/06/13)

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.

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