40648-96-2Relevant articles and documents
AROMATIC DERIVATIVES, PREPARATION METHODS, AND MEDICAL USES THEREOF
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Paragraph 0151, (2020/09/19)
The present disclosure relates generally to aromatic derivatives that are inhibitors of FGFR4 and are useful in treating FGFR4-associated diseases or conditions. Compositions containing the compounds of the present disclosure are also provided.
SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF
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Paragraph 0166, (2015/02/25)
Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.
ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2
Kiselyov, Alexander S.,Piatnitski, Evgueni L.,Samet, Alexander V.,Kisliy, Victor P.,Semenov, Victor V.
, p. 1369 - 1375 (2007/10/03)
We have developed a series of novel potent ortho-substituted azole derivatives active against kinases VEGFR-1 and VEGFR-2. Both specific and dual ATP-competitive inhibitors of VEGFR-2 were identified. Kinase activity and selectivity could be controlled by varying the arylamido substituents at the azole ring. The most specific molecule (17) displayed >10-fold selectivity for VEGFR-2 over VEGFR-1. Compound activities in enzymatic and cell-based assays were in the range of activities for reported clinical and development candidates (IC50 30 × 10-5 cm/min) is indicative of their potential for intestinal absorption upon oral administration.
Hetaryl imidazoles: A novel dual inhibitors of VEGF receptors I and II
Kiselyov, Alexander S.,Semenova, Marina,Semenov, Victor V.
, p. 1440 - 1444 (2007/10/03)
A novel potent derivatives of hetaryl imidazoles were described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Several compounds display VEGFR-2 inhibitory activity reaching IC50 100 nM in both enzymatic and cellular assays. The compounds also inhibit the related tyrosine kinase, VEGFR-1. By controlling the substitution pattern on the 5-carboxamido functionality, both dual and specific VEGFR-2 thiazoles were identified.
Nucleophilic Displacements of Imidazoles.I. Oxygen,Nitrogen and Carbon Nucleophiles
Kulkarni, Surendra,Grimmett, M. Ross,Hanton, Lyall R.,Simpson, Jim
, p. 1399 - 1413 (2007/10/02)
4(5)-Bromo- and -iodo-imidazoles, activated by an adjacent nitro substituent, undergo nucleophilic displacement with methoxide, phenoxide, cyclic secondary amines and cyanide.The regiochemistry of the reactions of 5-iodo-4-nitroimidazole with methoxide has been confirmed by spectroscopic and X-ray methods, and a number of erroneous structures from the literature have been revised.Some apparently anomalous reactions of methoxide with 5-halo-1,2-dimethyl-4-nitroimidazoles, and of cyanide with 4-halo-1-methyl-5-nitroimidazole have been noted.The crystal and molecular structure of 5-methoxy-1-methyl-4-nitroimidazole has been determined by direct methods.Crystals are monoclinic, P21/c, a 10.929(3), b 8.899(2), c 7.290(2) Angstroem; β 92.87(2) deg; Z 4.The structure was refined to R=0.095 for 818 reflections (I.2?I).
Nucleophilic Displacements of Imidazoles.II Displacements of Halogen by S-Nucleophiles and Displacements of Mesyl Groups Activated by Nitro; Oxidation of Imidazolethiols
Kulkarni, Surendra,Grimmett, M. Ross
, p. 1415 - 1425 (2007/10/02)
In basic medium arylthiols displace bromo and iodo groups activated by nitro substituents in 5(4)-halo-4(5)-nitroimidazoles.The bromo compounds are slightly more reactive than the iodo analogues.Substituents at C5 are more readily displaced than those at
