- NOVEL PROCESS FOR THE PREPARATION OF TOLTERODINE
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The present invention relates to a novel and improved process for the preparation of tolterodine of formula I. Key steps involved in the process are a vinyl Grignard reaction on a benzophenone derivative of formula XXI to get the vinyl carbinol derivative
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Page/Page column 13-14
(2010/11/26)
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- Tf2O as a rapid and efficient promoter for the dehydrative Friedel-Crafts acylation of aromatic compounds with carboxylic acids
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The Friedel-Crafts acylation of aromatic compounds with carboxylic acids was investigated in the presence of Tf2O. The reaction was carried out efficiently and very rapidly under mild reaction conditions without the need of any catalyst.
- Khodaei, Mohammd Mehdi,Alizadeh, Abdolhamid,Nazari, Ehsan
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p. 4199 - 4202
(2008/02/05)
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- METHOD OF OBTAINING TOLTERODINE
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The process comprises reacting a compound of formula (II), where R is a hydroxyl protecting group, and the asterisk indicates an asymmetric carbon atom, with diisopropylamine in the presence of a reducing agent; optionally converting the resulting intermediate into a salt and, if so desired, isolating it; removing the hydroxyl protecting group; and if so desired, separating the desired (R) or (S) enantiomer, or the mixture of enantiomers and/or converting the obtained compound into a pharmaceutically acceptable salt thereof. Tolterodine is a muscarinic receptor antagonist useful in treating urinary incontinence and other symptoms of urinary bladder hyperactivity.
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Page/Page column 8
(2008/06/13)
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- Method for producing 3,3-diarylpropylamines
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The invention relates to a novel method for producing 3,3-diarylpropylamines of formula (I), wherein A represents a substituted or unsubstituted aryl radical, X represents H, OH or OR3 and Y, R1, R2 and R3 have
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- Aluminum dodecatungstophosphate (AlPW12O40) as a non-hygroscopic Lewis acid catalyst for the efficient Friedel-Crafts acylation of aromatic compounds under solvent-less conditions
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Stable and non-hygroscopic aluminum dodecatungstophosphate (AlPW 12O40), which is prepared easily from cheap and commercially available compounds was found to be an effective catalyst for Friedel-Crafts acylation reactions using carboxylic acids, acetic anhydride and benzoyl chloride in the absence of solvent under mild reaction conditions.
- Firouzabadi, Habib,Iranpoor, Nasser,Nowrouzi, Farhad
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p. 10843 - 10850
(2007/10/03)
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- Solvent-free Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of trifluoroacetic anhydride and aluminum dodecatungstophosphate
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The stable and non-hygroscopic aluminum dodecatungstophosphate (AlPW12O40), was found to be an effective catalyst (3 mol%) for the solvent-free Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of trifluoroacetic anhydride under mild reaction conditions.
- Firouzabadi, Habib,Iranpoor, Nasser,Nowrouzi, Farhad
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p. 5343 - 5345
(2007/10/03)
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