40889-91-6

Basic information

• Product Name: 2-CHLORO-5-(TRIFLUOROMETHYL)PHENOL
• Synonyms: 4-CHLORO-3-HYDROXYBENZOTRIFLUORIDE;3-HYDROXY-4-CHLOROBENZOTRIFLUORIDE;2-CHLORO-5-(TRIFLUOROMETHYL)PHENOL;4-Chloro-3-hydroxybenzotrifluoride 98%;4-Chloro-3-hydroxybenzotrifluoride98%;2-Chloro-5-(trifluoromethyl)phenol, 6-Chloro-alpha,alpha,alpha-trifluoro-m-cresol;40889-91-6;2-Chloro-5-(trifluoromethyl)phenol 96%
• CAS NO: 40889-91-6
• Molecular Formula: C₇H₄ClF₃O
• Molecular Weight: 196.5542696
• EINECS: -0
• Product Categories: Phenol&Thiophenol&Mercaptan;Organic Building Blocks;Oxygen Compounds;Phenols
• Mol File: 40889-91-6.mol

Chemical Properties

• Boiling Point: 87-88 °C38 mm Hg(lit.)
• Flash Point: 115 °F
• Appearance: /
• Density: 1.459 g/mL at 25 °C(lit.)
• Vapor Pressure: 32mmHg at 25°C
• Refractive Index: n20/D 1.473(lit.)
• Storage Temp.: 2-8°C
• PKA: 7.49±0.10(Predicted)
• BRN: 2094176
• CAS DataBase Reference: 2-CHLORO-5-(TRIFLUOROMETHYL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-(TRIFLUOROMETHYL)PHENOL(40889-91-6)
• EPA Substance Registry System: 2-CHLORO-5-(TRIFLUOROMETHYL)PHENOL(40889-91-6)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 40889-91-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-5-(trifluoromethyl)phenol is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved efficacy and reduced side effects. It can be used in the production of antibiotics, anti-inflammatory agents, and other therapeutic molecules.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chloro-5-(trifluoromethyl)phenol is utilized as a key building block for the development of novel pesticides and herbicides. Its chemical properties enable the creation of compounds with enhanced target specificity, reduced environmental impact, and improved resistance management.
Used in Chemical Synthesis:
2-Chloro-5-(trifluoromethyl)phenol serves as a valuable starting material for the synthesis of various organic compounds, including dyes, polymers, and specialty chemicals. Its reactivity and stability make it an attractive candidate for use in the development of new materials with unique properties and applications.
Used in Material Science:
The unique structure of 2-Chloro-5-(trifluoromethyl)phenol allows it to be used in the development of advanced materials with specific properties. It can be incorporated into the design of new polymers, coatings, and composites with improved mechanical, thermal, and chemical resistance.

InChI:InChI=1/C6F14O3/c7-1(8,3(11,12)22-5(15,16)17)21-2(9,10)4(13,14)23-6(18,19)20

Upstream product

• 98-17-9 3-Trifluoromethylphenol 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 

Downstream Products

• 852109-85-4 2-allyl-6-chloro-3-(trifluoromethyl)phenol 
• 1266244-57-8 C₁₁H₁₁ClF₃NO 
• 1343889-45-1 5-chloro-3-[4-(2-chloro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-1-methyl-1H-pyrazin-2-one 
• 1345117-44-3 5-(2-chloro-5-(trifluoromethyl)phenoxy)-2-nitropyridine 
• 1345117-46-5 5-(2-chloro-5-(trifluoromethyl)phenoxy)pyridin-2-amine 
• 1345117-42-1 N-(5-(2-chloro-5-(trifluoromethyl)phenoxy)pyridin-2-yl)-2,6-difluorobenzamide 
• 1319196-88-7 2-bromo-1-((2-chloro-5-(trifluoromethyl)phenoxy)methyl)-3-methylbenzene 
• 1266244-56-7 C₂₄H₂₁ClF₃NO 

Relevant articles and documents

Novel 2,3-dihydrobenzofuran-2-carboxylic acids: Highly potent and subtype-selective PPARα agonists with potent hypolipidemic activity

The design and synthesis of a novel class of 2,3-dihydrobenzofuran-2- carboxylic acids as highly potent and subtype-selective PPARα agonists are reported. Systematic study of structure-activity relationships has identified several key structural elements within this class for maintaining the potency and subtype selectivity. Select compounds were evaluated in animal models of dyslipidemia using Syrian hamsters and male Beagle dogs, and all these compounds displayed excellent cholesterol- and triglyceride-lowering activity at dose levels that were much lower than the marketed weak PPARα agonist fenofibrate.

6-(Nonsubstituted or substituted) phenoxy picolinic acids, process of preparing the same, and agricultural/horticultural germicides containing the same

An agricultural or horticultural fungicide containing 6-(unsubstituted or substituted) phenoxy picolinic acid represented by the general formula (I), as an effective ingredient. wherein R is a halogen atom, a C1to C4alkyl group, a C1to C4haloalkyl group, a C1to C4alkoxy group, a C1to C4haloalkoxy group, a C1to C4alkylthio group, a C1to C4alkylamino group, a di(C1to C4alkyl)amino group or a C7to C8aralkyl(C1to C4alkyl)amino group; n2is an integer of 0 to 3; Y is a C1to C4alkyl group, a C1to C4haloalkyl group, a C1to C4alkoxy group, a C1to C4haloalkoxy group, a C1to C4alkylthio group, a C1to C4haloalkylthio group or a halogen atom; and m is an integer of 0 to 5, and when m and n2are not less than 2, Rs and Ys may be the same or different, respectively. The compound is useful as an effective ingredient of agricultural or horticultural fungicides.