41444-33-1

Basic information

• Product Name: 1-(2-Thienylthio)acetone
• Synonyms: 1-(2-THIENYLTHIO)ACETONE;(2-THIENYLTHIO)ACETONE;(THIEN-2-YLTHIO)ACETONE;1-(2-Thienylsulfanyl)acetone;(2-THIENYLTHIO)ACETONE 98%;1-Thiophen-2-ylsulfanylpropan-2-one
• CAS NO: 41444-33-1
• Molecular Formula: C₇H₈OS₂
• Molecular Weight: 172.27
• Mol File: 41444-33-1.mol

Chemical Properties

• Boiling Point: 260.8°C at 760 mmHg
• Flash Point: 111.5°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 1-(2-Thienylthio)acetone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Thienylthio)acetone(41444-33-1)
• EPA Substance Registry System: 1-(2-Thienylthio)acetone(41444-33-1)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 41444-33-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
1-(2-Thienylthio)acetone is used as a pharmaceutical agent for the treatment of cystinuria and nephrolithiasis, conditions characterized by the formation of kidney stones due to an excess of certain amino acids in the urine. Its chelating properties enable it to bind to these amino acids, reducing their concentration and preventing stone formation.
Used in Heavy Metal Detoxification:
As a chelating agent, 1-(2-Thienylthio)acetone is used for heavy metal detoxification, where it binds to and helps remove heavy metals from the body, mitigating their toxic effects.
Used in Antioxidant and Anti-Inflammatory Research:
1-(2-Thienylthio)acetone is used in research for its potential antioxidant and anti-inflammatory properties, which could contribute to the development of new therapeutic agents for various conditions.
Used in Chemical Synthesis:
In the chemical industry, 1-(2-Thienylthio)acetone is used in the synthesis of various organic compounds, contributing to the creation of new chemical entities with diverse applications.
Used as a Reagent in Chemical Reactions:
1-(2-Thienylthio)acetone serves as a reagent in chemical reactions, facilitating specific transformations and processes in the synthesis of target compounds.

InChI:InChI=1/C7H8OS2/c1-6(8)5-10-7-3-2-4-9-7/h2-4H,5H2,1H3

Upstream product

• 188290-36-0 thiophene 
• 35928-65-5 (methylthio)acetyl chloride 
• 88-15-3 2-Acetylthiophene 
• 624-92-0 Dimethyldisulphide 
• 10531-41-6 2-Bromoacetylthiophene 
• 5188-07-8 sodium thiomethoxide 
• 2373-51-5 chloro-methylsulfanyl-methane 
• 229970-94-9 N‐methoxy‐N‐methyl‐2‐thiophenecarboxamide 

Downstream Products

• 1292821-94-3 C₂₄H₂₂N₂O₂S₂ 

Relevant articles and documents

Substituted α-Sulfur Methyl Carbanions: Effective Homologating Agents for the Chemoselective Preparation of β-Oxo Thioethers from Weinreb Amides

The proper generation of α-thiomethyllithium reagents via reductive lithiation or deprotonation followed by reaction with variously functionalized Weinreb amides represents an excellent method to access β-oxo thioethers. The procedure is adaptable to alky

Rh/DuanPhos-Catalyzed Asymmetric Hydrogenation of β-Acetylamino Vinylsulfides: An Approach to Chiral β-Acetylamino Sulfides

Rh/DuanPhos-catalyzed asymmetric hydrogenation of challenging β-acetylamino vinylsulfides has been developed, affording chiral β-acetylamino sulfides with high yields and excellent ee's (up to 99% ee). This novel methodology provides an efficient and concise synthetic route to chiral β-acetylamino sulfides. The potential utility of this protocol in the synthesis of Apremilast has also been disclosed.

SYNTHESIS AND CONFORMATIONAL ANALYSIS OF 2-METHYLTHIO DERIVATIVES OF 1-(2-THIENYL)ETHANOL AND THEIR O-METHYL DERIVATIVES

The synthesis and conformational analysis of the title compounds are reported.The conformational properties of the 2-thienyl derivatives, deduced from 1H-nmr and ir data, are compared with those for 2-furyl analogs and the results have been interpreted taking into account the stronger (OH...Ring) intramolecular association in the 2-furyl derivatives.

A CONVENIENT GENERAL ACCESS TO α-SULFENYLATED ACETOPHENONES AND ALKANONES

Friedel-Crafts acylation of arenes with methylthio- (1) or phenylthio-acetyl chloride (2) provides ready access to α-methylthio- or α-phenylthio-substituted acetophenones.The acyl chlorides 1 and 2 reacted also with organoaluminium reagents to give α-sulfenylated alkanones.