415943-88-3

Basic information

• Product Name: 5-(4-METHOXY-2-NITROPHENYL)-2-FURALDEHYDE
• Synonyms: TIMTEC-BB SBB009801;5-(4-METHOXY-2-NITRO-PHENYL)-FURAN-2-CARBALDEHYDE;5-(4-METHOXY-2-NITROPHENYL)-2-FURALDEHYDE;AKOS BBS-00006643;AKOS BB-7867;AURORA KA-4228;ASISCHEM B52553;ART-CHEM-BB B025394
• CAS NO: 415943-88-3
• Molecular Formula: C₁₂H₉NO₅
• Molecular Weight: 247.2
• Mol File: 415943-88-3.mol

Chemical Properties

• Boiling Point: 432.2°Cat760mmHg
• Flash Point: 215.2°C
• Appearance: /
• Density: 1.336g/cm³
• Vapor Pressure: 1.13E-07mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 5-(4-METHOXY-2-NITROPHENYL)-2-FURALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHOXY-2-NITROPHENYL)-2-FURALDEHYDE(415943-88-3)
• EPA Substance Registry System: 5-(4-METHOXY-2-NITROPHENYL)-2-FURALDEHYDE(415943-88-3)

Safety Data

• Hazardous Substances Data: 415943-88-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-Methoxy-2-nitrophenyl)-2-furaldehyde is used as a building block for the synthesis of various pharmaceuticals due to its versatile chemical structure and functional groups. Its ability to participate in nucleophilic addition and substitution reactions allows for the creation of a wide range of drug candidates.
Used in Agrochemical Industry:
5-(4-Methoxy-2-nitrophenyl)-2-furaldehyde is used as a starting material for the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure and functional groups enable the development of novel and effective compounds for agricultural applications.
Used in Organic Synthesis:
5-(4-Methoxy-2-nitrophenyl)-2-furaldehyde is used as a key intermediate in organic synthesis for the preparation of various organic compounds. Its reactivity and functional groups make it a valuable component in the synthesis of complex organic molecules.
Used in Drug Development:
5-(4-Methoxy-2-nitrophenyl)-2-furaldehyde is used as a potential candidate for drug development due to its demonstrated biological activities. Its ability to participate in various chemical reactions allows for the modification and optimization of its properties to target specific therapeutic applications.

InChI:InChI=1/C12H9NO5/c1-17-8-2-4-10(11(6-8)13(15)16)12-5-3-9(7-14)18-12/h2-7H,1H3

Upstream product

• 98-01-1 furfural 
• 119-25-5 4-methoxy-2-nitrobenzenediazonium chloride 
• 96-96-8 4-methoxy-2-nitroaniline 

Downstream Products

• 1619995-18-4 (E)-N-[5-(4-methoxy-2-nitrophenyl)furan-2-ylmethylidene]naphthalen-2-amine 
• 1619995-07-1 12-[5-(4-methoxy-2-nitrophenyl)furan-2-yl]-9,9-dimethyl-7,8,9,10-tetrahydrobenzo[a]acridin-11(12H)-one 
• 328243-60-3 ethyl 4-[5-(4-methoxy-2-nitrophenyl)furan-2-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1391113-90-8 C₂₃H₂₂N₄O₆S 
• 1391114-06-9 2-[1-{3-(2,4-dimethoxyphenyl)-5-(5-(4-methoxy-2-nitrophenyl)furan-2-yl)-4,5-dihydro-1H-pyrazolyl}]-4-(4-nitrophenyl)[1,3]thiazole 
• 1391113-76-0 C₂₂H₁₉NO₇ 
• 1352548-25-4 1-(6-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-2-yl)acetone 
• 1352548-34-5 N-[5-methoxy-2-(4-oxopentanoyl)phenyl]-4-methylbenzenesulfonamide 

Relevant articles and documents

5-Aryl-2-furaldehydes in the synthesis of tetrahydropyrimidinones by Biginelli reaction

5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with ethyl acetoacetate or acetylacetone and (thio)- urea in the presence of FeCl3·6H2O as a catalyst. A series of ethyl 4-(5-aryl-2-furyl)-6-methyl-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine- 5-carboxylates was obtained.

Synthesis of 12-hetaryl-9,9-dimethyl-7,8,9,10-tetrahydrobenzo[a]acridin- 11(12H)-ones

Three-component condensation of naphthalen-2-amine with 5-arylfuran(thiophene, N-methylpyrrole)-2-carbaldehyde and 5,5- dimethylcyclohexane-1,3-dione, as well as condensation of N-[(5- arylfuran(thiophen)-2-ylmethylidene]naphthalen-2-amine with 5,5- dimethylcyclohexane-1,3-dione gave the corresponding 12-[5-arylfuran(thiophen, N-methylpyrrol)-2-yl]-7,8,9,10-tetradrobenzo[a]acridin-11(12H)-ones.

A new simple route to the thieno[2,3-b]indole ring system

A simple and effective method has been elaborated for the synthesis of thieno[2,3-b]indole ring system. It is based on the electrophilic recyclization of 2-alkyl-5-(2-isothiocyanoaryl)furans in the presence of anhydrous AlCl 3. Georg Thieme Ver

Furan as a 1,3-diketone equivalent: the second type furan recyclization applied to indole synthesis

A new approach for the synthesis of indole derivatives based on protolytic recyclization of 2-alkyl-5-(2-tosylaminoaryl)-furans is described. The furan ring in this unusual transformation formally serves as a 1,3-diketone equivalent.