5-(4-Methoxy-2-nitrophenyl)-2-furaldehyde

Base Information

• Chemical Name: 5-(4-Methoxy-2-nitrophenyl)-2-furaldehyde
• CAS No.: 415943-88-3
• Molecular Formula: C12H9 N O5
• Molecular Weight: 247.207
• DSSTox Substance ID: DTXSID90354781
• Nikkaji Number: J1.894.760I
• Wikidata: Q82133193
• Mol file: 415943-88-3.mol

Synonyms:5-(4-methoxy-2-nitrophenyl)furan-2-carbaldehyde;415943-88-3;5-(4-methoxy-2-nitrophenyl)-2-furaldehyde;5-(4-Methoxy-2-nitro-phenyl)-furan-2-carbaldehyde;Cambridge id 5403456;Oprea1_118835;Oprea1_797165;DTXSID90354781;BBL003988;MFCD00606249;STK297133;AKOS000100228;VS-01470;BB 0217329;CS-0307680;EN300-04806;AB00084110-01;5-(4-methoxy-2-nitrophenyl)furan-2-carbalde-hyde;5-(4-Methoxy-2-nitro-phenyl)-furan-2-carbald ehyde;Z56921083

Chemical Property of 5-(4-Methoxy-2-nitrophenyl)-2-furaldehyde

Chemical Property:

• Vapor Pressure: 1.13E-07mmHg at 25°C
• Boiling Point: 432.2°Cat760mmHg
• Flash Point: 215.2°C
• PSA: 85.26000
• Density: 1.336g/cm³
• LogP: 3.19910
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 247.04807239
• Heavy Atom Count: 18
• Complexity: 316

Purity/Quality:

99% ^*data from raw suppliers

5-(4-Methoxy-2-nitrophenyl)-2-furaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C2=CC=C(O2)C=O)[N+](=O)[O-]

Technology Process of 5-(4-Methoxy-2-nitrophenyl)-2-furaldehyde

There total 2 articles about 5-(4-Methoxy-2-nitrophenyl)-2-furaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

furfural (98-01-1) + 4-methoxy-2-nitrobenzenediazonium chloride (119-25-5) → 5-(4-methoxy-2-nitrophenyl)furan-2-carbaldehyde (415943-88-3)

Guidance literature:

With copper(II) choride dihydrate; In acetone; at 0 - 30 ℃;

DOI:10.1134/S107042801406013X

Reference yield:

furfural (98-01-1) + 4-methoxy-2-nitroaniline (96-96-8) → 5-(4-methoxy-2-nitrophenyl)furan-2-carbaldehyde (415943-88-3)

Guidance literature:

4-methoxy-2-nitroaniline; With hydrogenchloride; In water; at 80 ℃; for 0.5h;

With sodium nitrite; In water; at -10 - 0 ℃; for 0.666667h;

furfural; copper dichloride; In water; acetone; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2006.04.080

Reference yield: 95.0%

5-(4-methoxy-2-nitrophenyl)furan-2-carbaldehyde (415943-88-3) → 2-methyl-5-(4-methoxy-2-nitrophenyl)-furan (1045704-65-1)

Guidance literature:

With aluminum (III) chloride; sodium tetrahydroborate; In tetrahydrofuran; at -10 ℃; Reflux;

DOI:10.1016/j.tet.2011.10.114

upstream raw materials:

furfural

4-methoxy-2-nitroaniline

4-methoxy-2-nitrobenzenediazonium chloride

Downstream raw materials:

5-(4-Chloro-3-methyl-phenoxymethyl)-4-{[1-[5-(4-methoxy-2-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazole-3-thione

4-{[1-[5-(4-Methoxy-2-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazole-3-thione

4-{[1-[5-(4-Methoxy-2-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amino}-5-methyl-2,4-dihydro-[1,2,4]triazole-3-thione

5-Ethyl-4-{[1-[5-(4-methoxy-2-nitro-phenyl)-furan-2-yl]-meth-(E)-ylidene]-amino}-2,4-dihydro-[1,2,4]triazole-3-thione