42260-39-9

Basic information

• Product Name: 2-CHLORO-4-PHENYLPYRIDINE
• Synonyms: 2-CHLORO-4-PHENYLPYRIDINE;2-Chloro-4-Phenyl pyrdine
• CAS NO: 42260-39-9
• Molecular Formula: C₁₁H₈ClN
• Molecular Weight: 189.64
• Mol File: 42260-39-9.mol

Chemical Properties

• Boiling Point: 303℃
• Flash Point: 166℃
• Appearance: /
• Density: 1.186
• Vapor Pressure: 0.00169mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-CHLORO-4-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-PHENYLPYRIDINE(42260-39-9)
• EPA Substance Registry System: 2-CHLORO-4-PHENYLPYRIDINE(42260-39-9)

Safety Data

• Hazardous Substances Data: 42260-39-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-phenylpyridine is used as a synthetic intermediate for the development of various pharmaceuticals. Its versatile chemical structure allows for the creation of a wide range of medicinal compounds, contributing to the advancement of new treatments and therapies.
Used in Agrochemical Industry:
In the agrochemical industry, 2-chloro-4-phenylpyridine is employed as a precursor in the synthesis of agrochemicals. Its use in this sector aids in the development of pesticides, herbicides, and other agricultural chemicals that are essential for maintaining crop health and productivity.
Used in Chemical Research and Development:
2-Chloro-4-phenylpyridine is utilized as a building block in the development of various functional materials in the chemical research and development sector. Its unique properties make it suitable for the creation of new materials with specific characteristics, such as improved stability, reactivity, or selectivity.
Used in Organic Compound Synthesis:
2-Chloro-4-phenylpyridine is used as a key intermediate in the synthesis of a variety of organic compounds. Its presence in these reactions allows for the formation of complex molecules with diverse applications across different industries.

InChI:InChI=1/C11H8ClN/c12-11-8-10(6-7-13-11)9-4-2-1-3-5-9/h1-8H

Upstream product

• 153034-86-7 2-chloro-4-iodopyridine 
• 98-80-6 phenylboronic acid 
• 780-69-8 triethoxyphenylsilane 
• 4406-77-3 2-Phenyl-1,3,2-dioxaborinane 
• 1131-61-9 4-Phenylpyridine 1-oxide 
• 591-51-5 phenyllithium 
• 458532-84-8 2-chloro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine 
• 17228-67-0 2-chloropyridin-4(1H)-one 
• 26452-80-2 2,4-dichloropyridine 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 73583-37-6 2-chloro-4-bromopyridine 
• 75061-73-3 dicyclopentadienylphenylzirconium(IV) chloride 
• 603-33-8 triphenylbismuthane 
• 14432-12-3 4-Amino-2-chloropyridine 

Downstream Products

• 54151-74-5 2-bromo-4-phenylpyridine 
• 883874-73-5 2-chloro-4-phenylpyridine 1-oxide 
• 18714-17-5 methyl 4-phenylpyridine-2-carboylate 
• 1241504-96-0 3-(4-phenylpyridin-2-yl)cyclohex-2-en-1-one 
• 1335148-36-1 C₂₄H₁₇ClN₂O 
• 1609374-06-2 2-methyl-8-(4-phenylpyridine-2-yl)benzofuro[2,3-b]pyridine 
• 81976-73-0 4-fenil-piperidin-2-one 
• 939-23-1 p-phenylpyridine 

Relevant articles and documents

Palladium-catalyzed c-4 selective coupling of 2,4-dichloropyridines and synthesis of pyridine-based dyes for live-cell imaging

An alternative process of Pd-catalyzed C-4 selective coupling of 2,4-dichloropyridines with boronic esters was developed, which afforded 24 examples of C-4 coupled pyridines in moderate to good yields. After further arylation, 21 examples of C-2, C-4 diarylated pyridines with a significant photophysical property were obtained, which were applied as pyridine-based dyes into live-cell imaging with good biocompatibility and low toxicity.

METAL COMPLEXES CONTAINING SUBSTITUTED PYRIDINE LIGANDS

Novel compounds with substituted pyridine ligands are disclosed, which can be used as emitters in an electroluminescent device. These novel complexes can provide highly saturated color and long lifetime, and good device performance. Also disclosed are an electroluminescent device and a formulation.

Modifying Emission Spectral Bandwidth of Phosphorescent Platinum(II) Complexes Through Synthetic Control

The design, synthesis, and characterization of a series of tetradentate cyclometalated Pt(II) complexes are reported. The platinum complexes have the general structure Pt(ppz-O-CbPy-R), where a tetradentate cyclometalating ligand is consisting of ppz (3,5

A new aromatic amine compound and its preparation and use (by machine translation)

The invention discloses a novel aromatic amine compound, and the compound molecule of the general formula: Wherein R1 , R2 , R3 Are hydrogen atom or the carbon atom number 1 - 30 alkyl or the carbon atom number 6 - 50 car

TRICYCLIC DERIVATIVE

Disclosed are compounds useful as inhibitors of phosphodiesterase 1 (PDE1), compositions thereof, and methods of using the same.

Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates

A selection of heteroaryl fluorosulfates were readily synthesized using commercial SO2F2 gas. These substrates are highly efficient coupling partners in the Suzuki reaction. Through judicious selection of Pd catalysts the fluorosulfate functionality is differentiated from bromide and chloride; the order of reactivity being: -Br> -OSO2F> -Cl. Exploiting this trend allowed the stepwise chemoselective synthesis of a number of polysubstituted pyridines, including the drug Etoricoxib. A selection of heteroaryl fluorosulfates were readily synthesized using commercial SO2F2 gas. These substrates are highly efficient coupling partners in the Suzuki reaction. Through judicious selection of Pd catalysts the fluorosulfate functionality is differentiated from bromide and chloride; the order of reactivity being: -Br> -OSO2F> -Cl. Exploiting this trend allowed the stepwise chemoselective synthesis of a number of polysubstituted pyridines, including the drug Etoricoxib.

Synthesis and utility of dihydropyridine boronic esters

When activated by an acylating agent, pyridine boronic esters react with organometallic reagents to form a dihydropyridine boronic ester. This intermediate allows access to a number of valuable substituted pyridine, dihydropyridine, and piperidine products.

Copper-catalysed cross-coupling of arylzirconium reagents with aryl and heteroaryl iodides

An unprecedented CuI-catalysed cross-coupling of arylzirconium reagents with aryl and heteroaryl iodides is reported. Mechanistic studies with a Cp2ZrAr2 complex revealed that Cp2Zr(Ar)(Cl) is the reactive species that undergoes transmetalation with (PN-1)CuI. In addition, experiments with radical probes indicated that the reaction proceeds via a non-radical pathway. This journal is

Copper-Catalyzed Coupling of Triaryl- and Trialkylindium Reagents with Aryl Iodides and Bromides through Consecutive Transmetalations

An efficient copper(I)-catalyzed coupling of triaryl and trialkylindium reagents with aryl iodides and bromides is reported. The reaction proceeds at low catalyst loadings (2 mol %) and generally only requires 0.33 equivalents of the triorganoindium reagent with respect to the aryl halide as all three organic nucleophilic moieties of the reagent are transferred to the products through consecutive transmetalations. The reaction tolerates a variety of functional groups and sterically hindered substrates. Furthermore, preliminary mechanistic studies that entailed the synthesis and characterization of potential reaction intermediates offered a glimpse of the elementary steps that constitute the catalytic cycle.

Facile Route to 2-Fluoropyridines via 2-Pyridyltrialkylammonium Salts Prepared from Pyridine N-Oxides and Application to 18F-Labeling

Among known precursors for 2-[18F]fluoropyridines, pyridyltrialkylammonium salts have shown excellent reactivity; however, their broader utility has been limited because synthetic methods for their preparation suffer from poor functional group