18714-17-5

Basic information

• Product Name: 4-Phenylpyridine-2-carboxylic acid methyl ester
• Synonyms: 4-Phenylpyridine-2-carboxylic acid methyl ester;Methyl 4-phenylpicolinate
• CAS NO: 18714-17-5
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.23194
• Mol File: 18714-17-5.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Phenylpyridine-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenylpyridine-2-carboxylic acid methyl ester(18714-17-5)
• EPA Substance Registry System: 4-Phenylpyridine-2-carboxylic acid methyl ester(18714-17-5)

Safety Data

• Hazardous Substances Data: 18714-17-5(Hazardous Substances Data)

Upstream product

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 98-80-6 phenylboronic acid 
• 107969-78-8 methyl benzylidenepyruvate 
• 75-07-0 acetaldehyde 
• 29681-42-3 methyl 4-bromopyridine-2-carboxylate 
• 768-03-6 Phenyl vinyl ketone 
• 821796-68-3 phenyl(1-tosylaziridin-2-yl)methanone 
• 585529-12-0 2-(1-phenylvinyl)-N-tosylaziridine 
• 683-98-7 methyl bromodifluoroacetate 
• 107969-78-8 methyl 4-phenyl-2-oxo-3-butenoate 
• 2459-07-6 methyl pyridine-2-carboxylate 
• 5470-22-4 4-chloropicolinic acid 
• 98-98-6 2-Picolinic acid 
• 380381-28-2 4-iodopyridine-2-carboxylic acid methyl ester 

Downstream Products

• 55218-73-0 2-(hydroxymethyl)-4-phenylpyridine 
• 261777-31-5 C₁₇H₂₃NO₄ 
• 261777-31-5 C₁₇H₂₃NO₄ 
• 1073461-87-6 N-((3S)-5-(4-methylpiperazin-1-yl)-3,4-dihydro-2H-chromen-3-yl)-4-phenylpyridine-2-carboxamide 

Relevant articles and documents

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2CReceptor-Positive Allosteric Modulators with Enhanced Drug-like Properties

Targeting the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) allosteric site to potentiate endogenous 5-HT tone may provide novel therapeutics to alleviate the impact of costly, chronic diseases such as obesity and substance use disorders. Expanding upon our recently described 5-HT2CR-positive allosteric modulators (PAMs) based on the 4-alkylpiperidine-2-carboxamide scaffold, we optimized the undecyl moiety at the 4-position with variations of cyclohexyl- or phenyl-containing fragments to reduce rotatable bonds and lipophilicity. Compound 12 (CTW0415) was discovered as a 5-HT2CR PAM with improved pharmacokinetics and reduced off-target interactions relative to our previous series of molecules. The in vivo efficacy of compound 12 to potentiate the effects of a selective 5-HT2CR agonist was established in a drug discrimination assay. Thus, 12 is reported as a 5-HT2CR PAM with characteristics suitable for in vivo pharmacological studies to further probe the biological and behavioral mechanisms of allosteric modulation of a receptor important in several chronic diseases.

SMALL MOLECULE CORRECTORS OF MAMMALIAN SLC6A8 FUNCTION

Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with mutation in a protein.

Allosteric modulators of 5-hydroxytryptamine 2C receptor (5-HT2CR)

The disclosure is directed to compounds identified as allosteric modulators of 5-HT 2CR, as well as pharmaceutical compositions and methods using the same. Certain embodiments also include methods of identifying and methods of synthesizing the compounds. Optimization and development of allosteric 5-HT 2CR modulators that bind sites other than the primary ligand binding site generate novel, highly selective, and potent ligands of 5-HT2CR. Such molecules can be used as small molecule probes for the nervous system and as effective therapeutics for a variety of diseases.