- SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS
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The present application relates to substituted fused heteroaryl and heterocyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase. (Formula I)
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Page/Page column 78-79
(2018/12/03)
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- NMR spectroscopic data of some 1-alkoxy-2,2-di(carbonyl, carboxyl, cyano)-substituted ethylenes
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The 1H-13C NMR shifts as well as 1H and 13C coupling constants of 14 alkoxymethylene malonic acid and acetoacetic acid derivatives and two alkoxymethylene acetylacetones are reported. The 17O NMR spectra have been recorded for six of them. The long-range coupling 3J(H-C=C-CR) has been used for determining the stereochemistry of the double bond. Copyright
- Hametner, Christian,Cernuchova, Petra,Milata, Viktor,Vo-Thanh, Giang,Loupy, Andre
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p. 171 - 173
(2007/10/03)
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- Condensation of ethyl (ethoxymethylene)cyanoacetate with Acyl- and diphenylphosphinylhydrazines
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Condensation of ethyl (ethoxymethylene)cyanoacetate with hydrazides of diphenylphosphinic acid and aliphatic and aromatic acids in ethanol involves exclusively the ethoxymethylene group and yields the corresponding ethyl 3-oxo-2-cyanopropanoate hydrazones. These compounds exist in the crystalline state and in solutions in the form of the enehydrazine tautomer in which the configurational equilibrium is determined by the nature of substituent in the hydrazine moiety.
- Bagrov
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p. 422 - 425
(2007/10/03)
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