- Novel Benzothiazole Ionic Liquids as Catalysts for the Synthesis of Parabens
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Abstract: A simple and green approach to the esterification of p-hydroxybenzoic acid and aliphatic alcohols to obtain parabens was developed. First, two novel benzothiazole ionic liquids [HBth]H2PW12O40 (IL1) and [HBth]H4PMo12O41 (IL2) were synthesized with benzothiazole and heteropolyacids as starting materials. The synthesized ionic liquids were characterized by FTIR spectroscopy, TGA, PXRD analysis, and SEM. The application of IL1 and IL2 as catalysts for the synthesis of parabens was explored. The results showed that the ILs had a high catalytic activity in the synthesis of parabens, and, at the same time, they could be easily recovered and reused five times without loss of activity.
- Liu, B.,Liu, Y.,Sun, J.,Yin, D.
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p. 1476 - 1483
(2020/10/02)
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- Ester Derivatives of 2,6-Bis(1-pyrrolidinylmethyl)-4-benzamidophenol as Short-Acting Antiarrhythmic Agents. 1
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In an effort to find a replacement for the iv antiarrhythmic drug lidocaine having reduced systemic and central nervous system effects, activity against supraventricular as well as ventricular arrhythmias, and a biological half-life of less than 15 min, derivatives of the orally active class Ic clinical agent 2,6-bis(1-pyrrolidinylmethyl)-4-benzamidophenol, 1 (ACC-9358), were synthesized and tested.Compounds with ester groups attached to the phenyl ring were either weakly active or toxic.Replacement of the formanilide function with alkyl esters afforded compounds with antiarrhythmic activity in the range of 1.When the ester carboxyl was separated from the bis(aminomethyl)phenol by methylene units, very short half-lives were observed in human blood.In general, these compounds also had low lipophilic character.
- Stout, David M.,Black, Lawrence A.,Barcelon-Yang, Cynthia,Matier, W. L.,Brown, Barry S.,et al.
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p. 1910 - 1913
(2007/10/02)
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