424803-19-0

Basic information

• Product Name: [5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL
• Synonyms: ASISCHEM A78094;[5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL;AKOS BB-7742;RARECHEM AL BD 1035;VITAS-BB TBB000573;ZERENEX E/5017744;{5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl}methanol
• CAS NO: 424803-19-0
• Molecular Formula: C₁₃H₈F₆O₂
• Molecular Weight: 310.19
• Mol File: 424803-19-0.mol

Chemical Properties

• Melting Point: 110 °C
• Boiling Point: 296.4°C at 760 mmHg
• Flash Point: 133.1°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0.000648mmHg at 25°C
• Refractive Index: 1.457
• CAS DataBase Reference: [5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL(424803-19-0)
• EPA Substance Registry System: [5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL(424803-19-0)

Safety Data

• Hazardous Substances Data: 424803-19-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
[5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs. [5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL's stability and reactivity make it a valuable building block in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical field, [5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL is used as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties allow for the creation of effective and stable agrochemical products.
Used in Materials Science:
[5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL is utilized in materials science for the development of new materials with specific properties. [5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL's unique structure can be functionalized to create materials with tailored characteristics for various applications, such as in coatings, adhesives, or polymers.
Overall, [5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2-FURYL]METHANOL's diverse applications across different industries highlight its importance in the fields of chemistry and biology, with potential for further research and development.

InChI:InChI=1/C13H8F6O2/c14-12(15,16)8-3-7(4-9(5-8)13(17,18)19)11-2-1-10(6-20)21-11/h1-5,20H,6H2

Upstream product

• 98-00-0 (2-furyl)methyl alcohol 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 127-08-2 potassium acetate 
• 256658-04-5 5-(3,5-bis(trifluoromethyl)phenyl)furan-2-carbaldehyde 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 73852-19-4 3,5-bis-trifluromethylphenylboronic acid 

Downstream Products

• 1198181-59-7 ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl}methoxy)acetate 
• 1198180-66-3 {5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}acetic acid 
• 1198180-65-2 ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetic acid 
• 1198181-63-3 {5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl}acetic acid 
• 1198181-62-2 {5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl}acetonitrile 
• 1198181-61-1 2-[3,5-bis(trifluoromethyl)phenyl]-5-(chloromethyl)furan 
• 1198181-60-0 ethyl ({5-[3,5-bis(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}methoxy)acetate 

Relevant articles and documents

The Influence of Substitution on Thiol-Induced Oxanorbornadiene Fragmentation

Oxanorbornadienes (ONDs) undergo facile Michael addition with thiols and then fragment by a retro-Diels-Alder (rDA) reaction, a unique two-step sequence among electrophilic cleavable linkages. The rDA reaction rate was explored as a function of the furan

HETEROCYCLIC COMPOUND

The present invention relates to a compound represented by wherein each symbol is as defined in the specification, a salt thereof and the like.

HETEROCYCLIC COMPOUND

The present invention relates to a compound represented by wherein each symbol is as defined in the specification, a salt thereof and the like.

Palladium-catalysed direct arylation of heteroaromatics bearing unprotected hydroxyalkyl functions using aryl bromides

Heteroaromatics bearing unprotected hydroxyalkyl functions can be arylated using aryl or heteroaryl bromides, via palladium-catalysed carbonhydrogen bond activation/arylation. Good yields were generally obtained using 0.01-0.5 mol% of the air-stable palladium acetate complex as the catalyst. The nature of the base was found to be crucial for the selectivity of this reaction. Potassium acetate led to the direct arylation products whereas caesium car-bonate led to the formation of the ether. This procedure is certainly more atom-economic than other methods for the preparation of such compounds, as no protection/ deprotection sequence of the hydroxyalkyl function and no preparation of an organometallic derivative is required.