428866-15-3

Basic information

• Product Name: 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE
• Synonyms: 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE
• CAS NO: 428866-15-3
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.2429
• Mol File: 428866-15-3.mol

Chemical Properties

• Boiling Point: 112 °C(Press: 7.3 Torr)
• Appearance: /
• Density: 0.984±0.06 g/cm3(Predicted)
• PKA: 3.35±0.10(Predicted)
• CAS DataBase Reference: 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE(428866-15-3)
• EPA Substance Registry System: 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE(428866-15-3)

Safety Data

• Hazardous Substances Data: 428866-15-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
DMPK is utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and agricultural products. Its unique structure allows for the creation of diverse chemical entities with potential therapeutic and pesticidal properties.
Used in Fine Chemical Production:
DMPK serves as a building block for the production of various fine chemicals, which are essential components in a wide range of applications, including fragrances, dyes, and specialty chemicals.
Used as a Reagent in Chemical Research and Organic Synthesis:
Due to its reactive nature, DMPK is employed as a reagent in chemical research and organic synthesis. It aids in the formation of new compounds and contributes to the advancement of scientific knowledge in the field of organic chemistry.

Upstream product

• 3510-66-5 2-Bromo-5-methylpyridine 
• 3282-30-2 pivaloyl chloride 
• 630-18-2 tert-butyl isocyanide 

Downstream Products

• 890151-27-6 2-[(R)-2,2-Dimethyl-1-(2,4,6-trimethyl-benzyloxy)-propyl]-5-methyl-pyridine 
• 890151-31-2 (R)-5-methyl-1-(1-(2,4,6-trimethyl)benzyloxy-2,2-dimethylpropyl)pyridine N-oxide 
• 890151-28-7 2-[(R)-2,2-Dimethyl-1-(2,4,6-triisopropyl-benzyloxy)-propyl]-5-methyl-pyridine 
• 890151-32-3 (R)-5-methyl-1-(1-(2,4,6-triisopropyl)benzyloxy-2,2-dimethylpropyl)pyridine N-oxide 

Relevant articles and documents

Scandium-bipyridine-catalyzed enantioselective aminolysis of meso-epoxides

The scandium-bipyridine-catalyzed enantioselective addition of anilines and O-alkyl hydroxylamines to meso-epoxides has been optimized and extended to a broad range of epoxides and amines. Whereas aromatic meso-epoxides generally furnished the corresponding 1.2-amino alcohols in Excellent enantioselectivities, aliphatic meso-epoxides only gave rise to moderate enantioselectivities in the aminolysis. The catalyst loading may be lowered to just 5 mol% with only marginal effects on yield and enantioselectivity. A strong positive nonlinear effect has been observed, pointing to aggregation phenomena of the catalyst.

Preparation of chiral bipyridine bis-N-oxides by oxidative dimerization of chiral pyridine N-oxides

The direct preparation of chiral 2,2′-bipyridine bis-N-oxides has been developed. The method involves two stages, first, the deprotonation of substituted chiral pyridine N-oxides and second, the oxidative dimerization of the resulting 2-lithiopyridine N-o

Lewis base catalyzed, enantioselective aldol addition of methyl trichlorosilyl ketene acetal to ketones

The catalytic enantioselective addition of an acetate enolate equivalent to ketones is described. Methyl trichlorosilyl ketene acetal reacts with a wide range of ketones in the presence of pyridine N-oxide to afford the aldol addition products in excellen

Catalytic, enantioselective aldol additions to ketones

Catalytic, enantioselective additions of a trichlorosilyl ketene acetal to ketones have been demonstrated. The trichlorosilyl enolate of methyl acetate undergoes a rapid and high-yielding aldol addition to a wide range of ketones (aromatic, olefinic, acet