2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE

Base Information

Chemical Name:2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE
CAS No.:428866-15-3
Molecular Formula:C₁₁H₁₅NO
Molecular Weight:177.246
Hs Code.:
Mol file:428866-15-3.mol

Synonyms:[2-(5-methylpyridyl)]-2,2-dimethylpropanone;2,2-Dimethyl-1-(5-methyl-pyridin-2-yl)-propan-1-one;

Suppliers and Price of 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE 95.00%
2G
$ 1674.75

Total 5 raw suppliers

Chemical Property of 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE

Chemical Property:

Boiling Point:112 °C (7.3 mmHg)
PKA:3.35±0.10(Predicted)
PSA：29.96000
Density:0.984±0.06 g/cm3(Predicted)
LogP:2.61880

Purity/Quality:

99% ^*data from raw suppliers

2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE

There total 2 articles about 2,2-DIMETHYL-1-(5-METHYL-PYRIDIN-2-YL)-PROPAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3510-66-5
2-Bromo-5-methylpyridine

: 3282-30-2
pivaloyl chloride

: 428866-15-3
2,2-dimethyl-1-(5-methylpyridin-2-yl)propan-1-one

Guidance literature:: 2-Bromo-5-methylpyridine; With n-butyllithium; In diethyl ether; hexane; at -73 ℃; for 1h;

pivaloyl chloride; In tetrahydrofuran; diethyl ether; hexane; at -73 - 20 ℃; for 9h;
DOI:10.1021/jo0506276

Reference yield: 89.0%

: 3510-66-5
2-Bromo-5-methylpyridine

: 630-18-2
tert-butyl isocyanide

: 428866-15-3
2,2-dimethyl-1-(5-methylpyridin-2-yl)propan-1-one

Guidance literature:: 2-Bromo-5-methylpyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

tert-butyl isocyanide; In diethyl ether; hexane; at -78 - 20 ℃; Further stages.;
DOI:10.1002/chem.200601307

Reference yield:

: 428866-15-3
2,2-dimethyl-1-(5-methylpyridin-2-yl)propan-1-one

: 890151-27-6
2-[(R)-2,2-Dimethyl-1-(2,4,6-trimethyl-benzyloxy)-propyl]-5-methyl-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: (-)-(Ipc)2BCl / tetrahydrofuran / 72 h / 20 °C

1.2: diethanolamine / tetrahydrofuran; diethyl ether / 3 h / 20 °C

2.1: potassium hydride / tetrahydrofuran

With potassium hydride; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran;
DOI:10.1016/j.tetasy.2005.12.039