4289-95-6

Basic information

• Product Name: N-FORMYL-DL-PHENYLALANINE
• Synonyms: N-FORMYL-DL-PHENYLALANINE;FOR-DL-PHE-OH;Formylphenylalanin;N-Formyl-DL-phenylalanin;N-FORMYL-DL-PHENYLALANINE 99+%;rac-(R*)-α-(Formylamino)benzenepropionic acid;2-ForMaMido-3-phenylpropanoic acid;N-Formyl-DL-phenylalanine
• CAS NO: 4289-95-6
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.2
• Mol File: 4289-95-6.mol

Chemical Properties

• Melting Point: 167 °C
• Boiling Point: 449.7 °C at 760 mmHg
• Flash Point: 225.8 °C
• Appearance: /
• Density: 1.235 g/cm³
• Storage Temp.: ?20°C
• Solubility: almost transparency in hot EtOH
• CAS DataBase Reference: N-FORMYL-DL-PHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-FORMYL-DL-PHENYLALANINE(4289-95-6)
• EPA Substance Registry System: N-FORMYL-DL-PHENYLALANINE(4289-95-6)

Safety Data

• Hazardous Substances Data: 4289-95-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
N-Formyl-DL-phenylalanine is used as a building block in peptide and protein synthesis for the development of new drugs and chemical compounds. Its role in the formation of the peptide bond makes it a valuable component in the creation of bioactive molecules with potential therapeutic properties.
Used in Cancer Treatment Research:
N-Formyl-DL-phenylalanine is used as a potential therapeutic agent in the treatment of various types of cancer. Its specific mechanisms of action and interactions with cellular pathways are under investigation to determine its efficacy and possible synergistic effects with existing cancer therapies.
Used in Neurodegenerative Disorder Research:
N-Formyl-DL-phenylalanine is used in the study of neurodegenerative disorders to explore its potential as a therapeutic intervention. Its role in protein synthesis and possible neuroprotective properties are being investigated to understand its potential impact on diseases such as Alzheimer's and Parkinson's.
Used in Biochemical Studies:
N-Formyl-DL-phenylalanine is used as a research tool in biochemistry to study the mechanisms of peptide bond formation and the role of formylated amino acids in various biological processes. This helps in advancing the understanding of protein synthesis and its regulation in living organisms.

Upstream product

• 150-30-1 Phenylalanine 
• 146039-03-4 N-(Diethylcarbamoyl)-N-methoxyformamide 
• 74010-51-8 (Z)-2-formamido-3-phenylacrylic acid 
• 65638-74-6 (Z)-N-Formyldehydrophenylalanin-methylester 
• 100-44-7 benzyl chloride 
• 100373-42-0 benzyl-formylamino-malonic acid dimethyl ester 
• 64-18-6 formic acid 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 13200-85-6 N-formyl-L-phenylalanine 
• 71731-72-1 Formyl-phenylalanyl-leucin-methylester 
• 71921-02-3 2-benzyl-2-formamidoacetic acid methyl ester 
• 15028-44-1 DL-phenylalanine methyl ester 
• 27395-19-3 N-formyl-phenylalanine amide 
• 91251-73-9 2-benzyl-2-methylaminoethanol 
• 59366-89-1 (-)-(R)-N-formylphenylalanine 
• 63-91-2 L-phenylalanine 
• 5030-45-5 (+/-)--N,N-bis-<2-brom-aethyl>-anilin 
• 16417-55-3 (+/-)-N-Formyl-phenylalanin-(2,4,6-trichlor-phenylester) 
• 150-30-1 Phenylalanine 
• 120301-86-2 N-(1-Benzyl-2-oxo-2-piperidin-1-yl-ethyl)-formamide 
• 85059-51-4 2-isocyano-3-phenyl-1-(pyrrolidin-1-yl)propan-1-one 
• 85059-38-7 2-isocyano-3-phenyl-1-(piperidin-1-yl)propan-1-one 

Relevant articles and documents

Divergent Synthesis of Enantioenriched β-Functional Amines via Desymmetrization of meso-Aziridines with Isocyanides

A highly enantioselective ring-opening desymmetrization of meso-aziridines with isocyanides was achieved in the presence of a chiral N,N′-dioxide/Mg(OTf)2 complex. The in situ generated chiral 1,4-zwitterionic intermediates were successfully trapped by intramolecular oxygen- and carbon-based nucleophiles or exogenous H2O and TMSN3, enabling a collective synthesis of various chiral vicinal amino-oxazoles, spiroindolines, β-amino amides, and tetrazole derivative in moderate to high yields with excellent enantioselectivities.

ANTIFOULING AGENT FOR UNDERWATER ADHERING ORGANISMS HAVING AMINO ACID ISONITRILE SKELETON

PROBLEM TO BE SOLVED: To provide a novel antifouling agent for underwater adhering organisms having excellent characteristics compared with well-known antifouling agents. SOLUTION: An antifouling agent for underwater adhering organisms comprises a compound represented by formula (I) or salt thereof, or solvate thereof, as an active ingredient. COPYRIGHT: (C)2015,JPO&INPIT

The Role of the Amino Protecting Group during Parahydrogenation of Protected Dehydroamino Acids

A series of dehydroamino acids endowed with different protective groups at the amino and carboxylate moieties and with different substituents at the double bond have been reacted with parahydrogen. The observed ParaHydrogen Induced Polarization (PHIP) effects in the 1H NMR spectra are strongly dependent on the amino protecting group. DFT calculations allowed us to establish a relationship between the structures of the reaction intermediates (whose energies depend on the amido substitution) and the observed PHIP patterns.

Synthesis of α-isocyano-α-alkyl(aryl)acetamides and their use in the multicomponent synthesis of 5-aminooxazole, pyrrolo[3,4-a]pyridin-5-one and 4,5,6,7-tetrahydrofuro[2,3-c]pyridine

α-Isocyano-β-phenylpropionamide 1 is synthesized from the corresponding amino acid in excellent yield. The unique reactivity of this bifunctional compound is exploited for the development of novel multicomponent synthesis of 5-aminooxazole 6, pyrrolo[3,4-

A new formylating reagent: N-(diethylcarbamoyl)-N-methoxyformamide

A simple and efficient method for the direct chemoselective formylation of primary amines in the presence of alcohols or secondary amines using a new reagent, N-(diethylcarbamoyl)-N-methoxyformamide is described.

N-formylation of amino carboxylic compounds with formamide

The amine nitrogen of an amino carboxylic acid is formylated by reacting the amino carboxylic acid with formamide.

REAGENTS AND SYNTHETIC METHODS. 30. PRACTICAL AND IMPROVED METHOD FOR FORMYLATING AMINO COMPOUNDS BY MEANS OF FORMIC ACID-DIMETHYLFORMAMIDE SYSTEM.

Several amino compounds were formylated in high yields by means of formic acid-dimethylformamide, specially D,L-amino acids.The influence of this solvent was also briefly discussed.

Autorecycling System for the Synthesis of α-Amino-acids by the Reductive Amination of α-Keto-acids catalysed by 1,5-Dihydro-5-deazaflavin

An effective autorecycling system for the biomimetic synthesis of α-amino-acids by the reductive amination of α-keto-acids has been achieved for the first time using 10-aryl-5-deazaflavin, ammonium formate, and formic acid; each mole of the 5-deazaflavin catalyses the reduction, by formic acid, of up to 20 moles of the α-imino-acids formed in situ from the α-keto-acids and ammonium formate.