4290-94-2

Basic information

• Product Name: 1-ETHYL-1H-INDOLE-2,3-DIONE
• Synonyms: AURORA 1402;IFLAB-BB F0347-1871;AKOS BBS-00001000;AKOS BC-1697;AKOS B029030;1-ETHYL-1H-INDOLE-2,3-DIONE;TIMTEC-BB SBB006825;1H-indole-2,3-dione, 1-ethyl-
• CAS NO: 4290-94-2
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Mol File: 4290-94-2.mol

Chemical Properties

• Boiling Point: 306.5°Cat760mmHg
• Flash Point: 140°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 0.000769mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-ETHYL-1H-INDOLE-2,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYL-1H-INDOLE-2,3-DIONE(4290-94-2)
• EPA Substance Registry System: 1-ETHYL-1H-INDOLE-2,3-DIONE(4290-94-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 4290-94-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Ethyl-1H-indole-2,3-dione is used as a key intermediate in the synthesis of various pharmaceuticals for its potential medicinal properties. It is particularly valued for its anti-inflammatory, anti-cancer, and anti-microbial effects, making it a promising candidate for the development of new drugs.
Used in Dye Industry:
Isatin is used as a precursor in the production of dyes, owing to its ability to form a variety of colored compounds. Its use in this industry is driven by the need for diverse colorants in textiles, cosmetics, and other applications.
Used in Chemical Industry:
1-Ethyl-1H-indole-2,3-dione is utilized in the synthesis of other organic compounds, showcasing its versatility and applicability in various chemical processes. Its role in this industry is to serve as a building block for the creation of new molecules with specific properties and functions.
Used in Fluorescent Dye Development:
Isatin is used as a component in the development of fluorescent dyes for various biological applications. Its incorporation into these dyes allows for enhanced visualization and tracking of biological processes, making it a valuable tool in research and diagnostics.

InChI:InChI=1/C10H9NO2/c1-2-11-8-6-4-3-5-7(8)9(12)10(11)13/h3-6H,2H2,1H3

Upstream product

• 369651-53-6 3-benzyl-1-ethyl-3-hydroxy-2,4(1H,3H)-quinolinedione 

Downstream Products

• 82355-81-5 1'-ethyl-1H,1'H-[2,3']biindolylidene-3,2'-dione 
• 14771-29-0 1-ethyl-3,3-diphenyl-indolin-2-one 
• 122767-27-5 1-ethyl-3,3-di-p-tolyl-indolin-2-one 
• 3922-17-6 1-ethyl-indoline-2,3-dione-3-oxime 
• 74375-44-3 o-ethylaminobenzamide 
• 139515-50-7 3-[(4,5-Diphenyl-oxazol-2-yl)-hydrazono]-1-ethyl-1,3-dihydro-indol-2-one 
• 79520-49-3 1-ethyl-2-oxo-5'-phenylindoline-3-spiro-2'-(1',3',4'-thiadiazol-4'-ine) 
• 86966-89-4 Hydroxy-diphenyl-acetic acid [1-ethyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 86966-92-9 Hydroxy-bis-(4-methoxy-phenyl)-acetic acid [1-ethyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 86966-91-8 Hydroxy-di-p-tolyl-acetic acid [1-ethyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 86966-90-7 Hydroxy-di-m-tolyl-acetic acid [1-ethyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 36047-55-9 5-Ethyl-5H-1,2,4-triazino<5,6-b>indol-3-thione 
• 129055-68-1 1-ethyl-3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one 
• 129055-72-7 3-(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)-1-ethyl-1,3-dihydro-3-hydroxy-2H-indol-2-one 

Relevant articles and documents

Novel ring contraction of 3-hydroxy-2,4(1H,3H)-quinolinediones in aqueous alkali. The first convenient route to 2-hydroxyindoxyls

Ring contraction of 3-hydroxy-2,4(1H, 3H)-quinolinediones (1) in aqueous potassium hydroxide resulted in the formation of 2-hydroxyindoxyls and/or dioxindoles. The choice of N-substituent and the reaction conditions govern the chemoselectivity of the reaction. N-Phenyl-substituted derivatives 1 give 2-hydroxyindoxyls, while N-alkyl- and N-benzyl-substituted derivatives afford the corresponding dioxindols. On the basis of byproduct analysis, as well as independent experiments, the most plausible reaction mechanism is proposed.