43163-94-6

Basic information

• Product Name: 3-FLUORO-DL-VALINE
• Synonyms: 2-Amino-3-fluoro-4-methylbutyric acid~H-3-F-DL-Val-OH;2-Amino-3-fluoro-4-methylbutyricacid;H-3-F-DL-Val-OH;3-Fluoro-DL-valine,94%;2-Amino-3-fluoro-3-methylButanoicacid;DL-Valine, 3-fluoro-;2-AMINO-3-FLUORO-3-METHYLBUTYRIC ACID;3-FLUOROVALINE
• CAS NO: 43163-94-6
• Molecular Formula: C₅H₁₀FNO₂
• Molecular Weight: 135.14
• EINECS: -0
• Product Categories: pharmacetical
• Mol File: 43163-94-6.mol

Chemical Properties

• Melting Point: ~210 °C (dec.)
• Boiling Point: 242.1 °C at 760 mmHg
• Flash Point: 100.2 °C
• Appearance: /
• Density: 1.172 g/cm³
• Vapor Pressure: 0.0115mmHg at 25°C
• Refractive Index: 1.44
• Storage Temp.: 2-8°C
• PKA: 1.91±0.12(Predicted)
• BRN: 2350377
• CAS DataBase Reference: 3-FLUORO-DL-VALINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-DL-VALINE(43163-94-6)
• EPA Substance Registry System: 3-FLUORO-DL-VALINE(43163-94-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 43163-94-6(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
3-Fluoro-DL-Valine is used as a research compound for its role in various biological studies, particularly in the fields of biochemistry, pharmacology, and molecular genetics. It aids in understanding the effects of fluorination on amino acid properties and their interactions within biological systems.
Used in Pharmaceutical Development:
3-Fluoro-DL-Valine is used as an intermediate in organic synthesis, contributing to the development of new pharmaceutical compounds. Its unique structure allows for the creation of novel drug candidates with potential therapeutic applications.
Used in Biochemical Studies:
3-Fluoro-DL-Valine is used as a biochemical tool to investigate the role of amino acids in enzyme reactions and protein synthesis. Its fluorinated nature provides insights into the mechanisms of biological processes and the potential for developing new therapeutic strategies.

InChI:InChI=1/C5H10FNO2/c1-5(2,6)3(7)4(8)9/h3H,7H2,1-2H3,(H,8,9)/t3-/m1/s1

Upstream product

• 50884-94-1 2-Bromo-3-fluoro-3-methyl-butyric acid 
• 79205-57-5 amino-2 fluoro-3 methyl-3 butanonitrile 
• 83611-25-0 3-fluoro-2-keto-3-methybutanoic acid 
• 4491-47-8 2-phenyl-4-isopropylidene-5(4H)oxazolone 
• 171078-05-0 4-Fluoro-4-(1-fluoro-1-methyl-ethyl)-2-phenyl-4H-oxazol-5-one 
• 26429-35-6 3-fluoro-2-hydroxy-3-methylbutanonitrile 
• 6509-07-5 3,3-dimethyloxirane-2-carbonitrile 
• 541-47-9 3-Methylbutenoic acid 
• 1620450-64-7 C₁₃H₁₆FNO₄ 

Downstream Products

• 171348-52-0 2-((tert-butoxycarbonyl)amino)-3-fluoro-3-methylbutanoic acid 
• 757242-20-9 (E)-(S)-4-({2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-3-methyl-3-phenyl-butyrylamino]-3-fluoro-3-methyl-butyryl}-methyl-amino)-2,5-dimethyl-hex-2-enoic acid 
• 293305-68-7 tert-butyl 2-fluoro-1,2-dimethylpropyl carbamate 
• 1620450-64-7 C₁₃H₁₆FNO₄ 
• 1620450-65-8 C₁₃H₁₆FNO₄ 
• 1620450-66-9 C₁₃H₁₆FNO₄ 

Relevant articles and documents

HETEROCYCLE-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES

The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A', R 2 R 3, R 4 and R are as defined herein. The present i

THIAZOLYL-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES

The present invention relates to novel Thiazolyl-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A', R2R3, R4 and R5 are as defined herein. The present

Addition of molecular fluorine to azlactones: General synthetic method of erythro-β-fluorinated α-amino acids

Reaction of molecular fluorine with unsaturated azlactones derived from appropriate aldehydes (or ketones) and benzoylglycine afforded the difluorinated adducts. The reductive amination reaction of the β-fluorinated α-oxoalkanoic acids obtained from the a

STEREOSPECIFIC SYNTHESIS OF 2-AMINO-3-FLUORONITRILES. PREPARATION OF β-FLUORO-α-AMINO ACID AND ESTERS

The synthesis of some 2-amino-3-fluoro-nitriles and 2-amino-3-fluoro-acids and their esters have been achieved by means of a Strecker-type reaction.The method involved the action of amines with 3-fluoro-2-hydroxy-nitriles followed by acid solvolysis.The f

NOUVELLE VOIE DE SYNTHESE D'ACIDES AMINES MONOFLUORES

Ring opening of the glycidonitriles (IIa-e) by HF/pyridine leads to the fluorocyanohydrins (IIIa-e).Treatment of the nitriles (IIIa-e) with ammonia in methanol gives the α-amino-β-fluoro nitriles (IVa-e) which upon acidic hydrolysis afford the β-fluoro-α-