6509-07-5Relevant academic research and scientific papers
Expedient synthesis of glycidonitriles by darzens condensation of α-halogenonitriles with aldehydes and ketones
Jonczyk,Gadaj
, p. 1595 - 1610 (2008/09/17)
Chloroacetonitrile (1), α-halogenopropionitriles 4, and α-chlorophenylacetonitrile (6) react with aldehydes 2a,b,h-o and ketones 2c-g,p-t in the presence of solid NaOH in THF or DME, without any added catalyst, affording substituted glycidonitriles 3a-t, 5a, c-g,r,s and 7a,b,i,j,u,v, respectively (Darzens condensation). The glycidonitriles 3a-h, prepared from 1 and carbonyl compounds 2a-h, are obtained in high yields, exceeding those reported in the literature (Table 5). Expedient results of the reactions studied are due to increased reactivity of anions with Na+ as counterion in ethereal solvents. Investigation of the concentration of NaOH and the carbanion of diphenylacetonitrile in selected solvents reveals that ethereal solvents may increase the solubility of the anions participating in Darzens condensation.
Insertion of metallated epoxynitriles into organozirconocene chlorides. A convergent synthesis of 2-cyano-1,3-dienes
Kasatkin,Whitby
, p. 6201 - 6205 (2007/10/03)
Lithiated epoxynitriles insert efficiently into alkenyizirconocene chlorides via a 1,2-metallate rearrangement to form intermediates which eliminate Cp2Zr(Cl)O- to afford substituted 2-cyano-1,3-dienes. (C) 2000 Elsevier Science Ltd.
NOUVELLE VOIE DE SYNTHESE D'ACIDES AMINES MONOFLUORES
Ayi, A. I.,Remli, M.,Guedj, R.
, p. 1505 - 1508 (2007/10/02)
Ring opening of the glycidonitriles (IIa-e) by HF/pyridine leads to the fluorocyanohydrins (IIIa-e).Treatment of the nitriles (IIIa-e) with ammonia in methanol gives the α-amino-β-fluoro nitriles (IVa-e) which upon acidic hydrolysis afford the β-fluoro-α-
Two-phase Darzens Condensation Reaction with Octopus Compounds as a Catalyst
Akabori, Sadatoshi,Ohtomi, Michiko,Yatabe, Seiichi
, p. 1463 - 1464 (2007/10/02)
The octopus compound, readily derived from hexakis(mercaptomethyl)benzene and 1-chloro-3,6,9-triozadecane, was effectively employed as a catalyst in the two-phase Darzens condensation of carbonyl compounds with chloroacetonitrile to afford the correspondi
