- Easy access to 2-alkyl and 2-arylthiazolines using a modified heteropolyacid catalysis: Application to the synthesis of bacillamide A
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A straightforward access to 2-alkyl and 2-arylthiazolines by condensation of-aminothiols on nitriles, catalyzed by phosphotungstic acid (2%) under microwave irradiation, is described. This method has been directly applied to a short and efficient synthesi
- Fache,Cros,Piva,Lefebvre
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experimental part
p. 2098 - 2109
(2012/06/04)
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- New carboxylic acid amides of the pyrrole series: Synthetic routes and biological aspects
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Complex II inhibitors play an important role in agrochemical fungicide research and have been known for more than 40 years. With the introduction of ortho-substituted heterocyclic amides, a breakthrough in activity level and spectrum within this class was achieved. In the meantime all major agrochemical companies have entered this field. In this paper, a special complex II subclass, the pyrrole carboxamides, will be introduced in more detail and the synthesis of selected compounds as well as a short biological SAR analysis of the pyrrole subclass will be discussed.
- Walter, Harald
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scheme or table
p. 351 - 362
(2009/01/31)
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- Studies on Amino Acid Derivatives. Part 7. General Method for the Synthesis of Penam and Cepham and Their Substituted Derivatives
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Penam (7-oxo-4-thia-1-azabicycloheptane), a basic skeleton of penicillin-type β-lactams, has been synthesized as a stable compound from thiazolidinylacetic acid.The key step in this synthesis is the formation of the β-lactam ring by Mukaiyama-Ohno's procedure.Three methods are developed for the synthesis of thiazolidinylacetic acid from cysteamine by reactions with ethyl propiolate, ethyl ethoxycarbonylacetimidate, or t-butyl formylacetate.Using appropriate derivatives of the latter compounds, 5-, 6-, and 5,6-substituted derivatives of penam are also synthesized.The yields of the bicyclic β-lactams are shown to be strongly dependent upon the pattern of substituents on the thiazolidinylacetic acid.The synthesis of cephams using homocysteamine is also described.
- Chiba, Takuo,Sakaki, Jun-ichi,Takahashi, Takumi,Aoki, Kumi,Kamiyama, Akiko,et al.
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p. 1845 - 1852
(2007/10/02)
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