43183-24-0Relevant academic research and scientific papers
Easy access to 2-alkyl and 2-arylthiazolines using a modified heteropolyacid catalysis: Application to the synthesis of bacillamide A
Fache,Cros,Piva,Lefebvre
experimental part, p. 2098 - 2109 (2012/06/04)
A straightforward access to 2-alkyl and 2-arylthiazolines by condensation of-aminothiols on nitriles, catalyzed by phosphotungstic acid (2%) under microwave irradiation, is described. This method has been directly applied to a short and efficient synthesi
New carboxylic acid amides of the pyrrole series: Synthetic routes and biological aspects
Walter, Harald
scheme or table, p. 351 - 362 (2009/01/31)
Complex II inhibitors play an important role in agrochemical fungicide research and have been known for more than 40 years. With the introduction of ortho-substituted heterocyclic amides, a breakthrough in activity level and spectrum within this class was achieved. In the meantime all major agrochemical companies have entered this field. In this paper, a special complex II subclass, the pyrrole carboxamides, will be introduced in more detail and the synthesis of selected compounds as well as a short biological SAR analysis of the pyrrole subclass will be discussed.
Studies on Amino Acid Derivatives. Part 7. General Method for the Synthesis of Penam and Cepham and Their Substituted Derivatives
Chiba, Takuo,Sakaki, Jun-ichi,Takahashi, Takumi,Aoki, Kumi,Kamiyama, Akiko,et al.
, p. 1845 - 1852 (2007/10/02)
Penam (7-oxo-4-thia-1-azabicycloheptane), a basic skeleton of penicillin-type β-lactams, has been synthesized as a stable compound from thiazolidinylacetic acid.The key step in this synthesis is the formation of the β-lactam ring by Mukaiyama-Ohno's procedure.Three methods are developed for the synthesis of thiazolidinylacetic acid from cysteamine by reactions with ethyl propiolate, ethyl ethoxycarbonylacetimidate, or t-butyl formylacetate.Using appropriate derivatives of the latter compounds, 5-, 6-, and 5,6-substituted derivatives of penam are also synthesized.The yields of the bicyclic β-lactams are shown to be strongly dependent upon the pattern of substituents on the thiazolidinylacetic acid.The synthesis of cephams using homocysteamine is also described.
