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2-Chloro-4-(2,2,2-trifluoroethoxy)phenol, commonly known as Triclosan, is a synthetic chemical compound characterized by its broad-spectrum antibacterial and antifungal properties. It is distinguished by its ability to inhibit the growth of bacteria and fungi, which makes it a versatile ingredient in various consumer products and medical applications.

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  • 444341-80-4 Structure
  • Basic information

    1. Product Name: 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL
    2. Synonyms: 2-CHLORO-4-(TRIFLUOROETHOXY)-PHENOL;2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL
    3. CAS NO:444341-80-4
    4. Molecular Formula: C8H6ClF3O2
    5. Molecular Weight: 226.58
    6. EINECS: N/A
    7. Product Categories: Phenol&Thiophenol&Mercaptan
    8. Mol File: 444341-80-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 243.382 °C at 760 mmHg
    3. Flash Point: 100.994 °C
    4. Appearance: /
    5. Density: 1.446 g/cm3
    6. Vapor Pressure: 0.021mmHg at 25°C
    7. Refractive Index: 1.484
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL(444341-80-4)
    12. EPA Substance Registry System: 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL(444341-80-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: 36/37/38
    3. Safety Statements: 26-36/37/39
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 444341-80-4(Hazardous Substances Data)

444341-80-4 Usage

Uses

Used in Personal Care Products:
2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL is used as an antibacterial and antifungal agent for its effectiveness in preventing odors and the spread of infections in products such as soaps, toothpaste, and hand sanitizers.
Used in Medical Devices:
In the medical industry, 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL is used as a preservative and disinfectant to prevent microbial growth on medical devices, ensuring their safety and efficacy.
Used in Textiles and Plastics:
2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL is used as an additive in textiles and plastics to provide antimicrobial properties, enhancing the durability and cleanliness of these materials.
However, the widespread use of 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL has raised environmental and health concerns due to its potential to accumulate in the environment and marine life, and its possible negative effects on hormone functioning and resistance to antibiotics. Consequently, several countries have taken measures to ban or restrict its use in certain products, reflecting the need for ongoing evaluation of its benefits and risks.

Check Digit Verification of cas no

The CAS Registry Mumber 444341-80-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,4,3,4 and 1 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 444341-80:
(8*4)+(7*4)+(6*4)+(5*3)+(4*4)+(3*1)+(2*8)+(1*0)=134
134 % 10 = 4
So 444341-80-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H6ClF3O2/c9-6-3-5(1-2-7(6)13)14-4-8(10,11)12/h1-3,13H,4H2

444341-80-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:444341-80-4 SDS

444341-80-4Relevant articles and documents

Novel 2,3-dihydrobenzofuran-2-carboxylic acids: Highly potent and subtype-selective PPARα agonists with potent hypolipidemic activity

Shi, Guo Q.,Dropinski, James F.,Zhang, Yong,Santini, Conrad,Sahoo, Soumya P.,Berger, Joel P.,MacNaul, Karen L.,Zhou, Gaochao,Agrawal, Arun,Alvaro, Raul,Cai, Tian-Quan,Hernandez, Melba,Wright, Samuel D.,Moller, David E.,Heck, James V.,Meinke, Peter T.

, p. 5589 - 5599 (2007/10/03)

The design and synthesis of a novel class of 2,3-dihydrobenzofuran-2- carboxylic acids as highly potent and subtype-selective PPARα agonists are reported. Systematic study of structure-activity relationships has identified several key structural elements within this class for maintaining the potency and subtype selectivity. Select compounds were evaluated in animal models of dyslipidemia using Syrian hamsters and male Beagle dogs, and all these compounds displayed excellent cholesterol- and triglyceride-lowering activity at dose levels that were much lower than the marketed weak PPARα agonist fenofibrate.

(2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents

Koyama, Hiroo,Boueres, Julia K.,Miller, Daniel J.,Berger, Joel P.,MacNaul, Karen L.,Wang, Pei-Ran,Ippolito, Marc C.,Wright, Samuel D.,Agrawal, Arun K.,Moller, David E.,Sahoo, Soumya P.

, p. 3347 - 3351 (2007/10/03)

A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonisim. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in hamster and dog animal models.

Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders

-

, (2008/06/13)

A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, d

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