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448202-03-7

N,1-diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 448202-03-7 Structure

  • Basic information

    1. Product Name: N,1-diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide
    2. Synonyms: N,1-diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide
    3. CAS NO:448202-03-7
    4. Molecular Formula: C15H16N2O3S
    5. Molecular Weight: 304.36414
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 448202-03-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N,1-diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N,1-diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide(448202-03-7)
    11. EPA Substance Registry System: N,1-diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide(448202-03-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 448202-03-7(Hazardous Substances Data)

448202-03-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 448202-03-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,8,2,0 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 448202-03:
(8*4)+(7*4)+(6*8)+(5*2)+(4*0)+(3*2)+(2*0)+(1*3)=127
127 % 10 = 7
So 448202-03-7 is a valid CAS Registry Number.

448202-03-7Downstream Products

448202-03-7Relevant articles and documents

2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof

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Paragraph 0322; 0323; 0324; 0379; 0380, (2018/02/28)

The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the BET bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, inflammatory diseases, and autoimmune disorders, sepsis, and viral infections.

Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation

Xue, Xiaoqian,Zhang, Yan,Liu, Zhaoxuan,Song, Ming,Xing, Yanli,Xiang, Qiuping,Wang, Zhen,Tu, Zhengchao,Zhou, Yulai,Ding, Ke,Xu, Yong

, p. 1565 - 1579 (2016/03/05)

The discovery of inhibitors of bromodomain and extra terminal domain (BET) has achieved great progress, and at least seven inhibitors have progressed into clinical trials for the treatment of cancer or inflammatory diseases. Here, we describe the identification, optimization, and evaluation of benzo[cd]indol-2(1H)-one containing compounds as a new class of BET bromodomain inhibitors, starting from structure-based virtual screening (SBVS). Through structure-based optimization, potent compounds were obtained with significantly improved activity. The two most potent compounds bind to the BRD4 bromodomain, with Kd values of 124 and 137 nM. Selected compounds exhibited high selectivity over other non-BET subfamily members. Notably, compound 85 demonstrated a reasonable antiproliferation effect on MV4;11 leukemia cells and exhibited a good pharmacokinetic profile with high oral bioavailability (75.8%) and moderate half-life (T1/2 = 3.95 h). The resulting lead molecule 85 represents a new, potent, and selective class of BET bromodomain inhibitors for the development of therapeutics to treat cancer and inflammatory diseases.

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